|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
Multivariate analysis indicated that IL-32 could be an independent prognostic factor in patients with colon cancer; therefore, IL-32 may be a novel prognostic biomarker and therapeutic target for colon cancer.
|
30988822 |
2019 |
|
Malignant tumor of colon
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
For example, IL-32γ and IL-32β expression is associated with increased cancer cell death in colon cancer and melanoma, whereas expression of these isoforms is associated with increased invasion and migration in breast cancer cells.
|
29747940 |
2018 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
Hence, it can be concluded that IL-32θ is an anti-inflammatory cytokine that can act as a tumor suppressor and can play vital role in colon cancer therapies.
|
29218075 |
2017 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
These findings provide evidence of the potential involvement of IL-32 in the development of obesity-associated CC as a pro-inflammatory and ECM remodeling cytokine.
|
28811968 |
2017 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
These findings indicate that IL-32α suppressed colon cancer development by promoting the death signaling of TNFR1.
|
25909160 |
2015 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
CTD_human |
Expression of acidosis-dependent genes in human cancer nests.
|
25279216 |
2014 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
IL-32γ enhances TNF-α-induced cell death in colon cancer.
|
23255489 |
2014 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
However, siRNA of NF-κB and STAT3 augmented IL-32γ-induced colon cancer cell growth inhibition.
|
21423208 |
2011 |
|
Malignant tumor of colon
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of the HGF-Met receptor pathway and tumor angiogenesis by NK4 gene expression has potential therapeutic value toward inhibition of invasion, growth, and metastasis of colon cancer.
|
17467663 |
2007 |
|
Malignant tumor of colon
|
0.390 |
Biomarker
|
disease |
BEFREE |
These findings indicate that NK4 gene transfer may be an effective tool for the treatment of colon cancer.
|
17461494 |
2007 |
|
Malignant neoplasm of stomach
|
0.360 |
Biomarker
|
disease |
BEFREE |
This emphasizes on unrecognized role of IL-32 in biology of diffuse type of gastric cancer.
|
30402092 |
2018 |
|
Malignant neoplasm of stomach
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Stratified analysis indicated that risks of GC and its precursors were elevated in subjects with IL-32 rs2015620 A allele (AA + AT) or IL-22 rs1179251 CC genotype and H. pylori infection, and significant interactions between these two SNPs and H. pylori infection were found.
|
26358252 |
2016 |
|
Malignant neoplasm of stomach
|
0.360 |
Biomarker
|
disease |
CTD_human |
Expression of acidosis-dependent genes in human cancer nests.
|
25279216 |
2014 |
|
Malignant neoplasm of stomach
|
0.360 |
Biomarker
|
disease |
BEFREE |
IL-32 contributes to gastric cancer progression by increasing the metastatic potential resulting from AKT, β-catenin, and HIF-1α activation.
|
24602839 |
2014 |
|
Malignant neoplasm of stomach
|
0.360 |
Biomarker
|
disease |
BEFREE |
Multivariate analysis demonstrated that IL-32 is one of the prognostic markers (p < 0.03) for gastric cancer, in addition to nodal involvement and tumor depth.
|
23479179 |
2013 |
|
Malignant neoplasm of stomach
|
0.360 |
Biomarker
|
disease |
BEFREE |
Levels of interleukin-32 (IL-32), a recently described inflammatory cytokine, are increased in various inflammatory diseases, such as rheumatoid arthritis and Crohn's disease, and in malignancies, including gastric cancer.
|
22890997 |
2012 |
|
Malignant neoplasm of stomach
|
0.360 |
Biomarker
|
disease |
BEFREE |
Therefore, the current study investigates whether adenoviral vector-mediated NK4 gene therapy has therapeutic potential for gastric cancer.
|
15026993 |
2004 |
|
Sezary Syndrome
|
0.310 |
Biomarker
|
disease |
CTD_human |
Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes.
|
26551670 |
2015 |
|
Colonic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Expression of acidosis-dependent genes in human cancer nests.
|
25279216 |
2014 |
|
Sezary Syndrome
|
0.310 |
Biomarker
|
disease |
BEFREE |
We also showed that IL-32 dose-dependently accelerated the proliferation of MF and SS cell lines in vitro, which was inhibited by blocking mitogen-activated protein kinase and NF-κB-mediated signaling.
|
24226419 |
2014 |
|
Colonic Neoplasms
|
0.310 |
Biomarker
|
group |
BEFREE |
In this study, we showed that IL-32γ inhibited tumor growth in IL-32γ-overexpressing transgenic mice inoculated with melanoma as well as colon tumor growth in xenograft nude mice inoculated with IL-32γ-transfected colon cancer cells (SW620).
|
21423208 |
2011 |
|
Kidney Neoplasm
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of acidosis-dependent genes in human cancer nests.
|
25279216 |
2014 |
|
Stomach Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Expression of acidosis-dependent genes in human cancer nests.
|
25279216 |
2014 |
|
Malignant neoplasm of kidney
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of acidosis-dependent genes in human cancer nests.
|
25279216 |
2014 |
|
Hereditary Diffuse Gastric Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression of acidosis-dependent genes in human cancer nests.
|
25279216 |
2014 |