|
Acquired Immunodeficiency Syndrome
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Deletion variants within the NF-kappa B activation domain of the LMP1 oncogene prevail in acquired immunodeficiency syndrome-related large cell lymphomas and human immunodeficiency virus-negative atypical lymphoproliferations.
|
8562956 |
1996 |
|
Acquired Immunodeficiency Syndrome
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Tumors from both patients with AIDS-associated non-Hodgkin's lymphoma were EBV-positive and expressed LMP1, whereas tumors from all three patients with Burkitt's tumors were positive for EBV but negative for LMP1.
|
9580648 |
1998 |
|
Acquired Immunodeficiency Syndrome
|
0.040 |
Biomarker
|
group |
BEFREE |
Deletion variants within the NF-kappaB activation domain of the LMP1 oncogene in acquired immunodeficiency syndrome-related large cell lymphomas, in prelymphomas and atypical lymphoproliferations.
|
9322886 |
1997 |
|
Acquired Immunodeficiency Syndrome
|
0.040 |
Biomarker
|
group |
BEFREE |
Thus, impaired immune system may account for the late proliferation of lymphoblastoid cells (Epstein-Barr nuclear antigen [EBNA]2positive/latent membrane protein [LMP]1 positive) in HIV-infected patients, and could explain why EBV-driven, acquired immunodeficiency syndrome (AIDS)-related, non-Hodgkin's lymphoma occur more frequently in patients with low CD4-positive T cells.
|
8600041 |
1996 |
|
Acute infectious disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We report the diversity of latent membrane protein 1 (LMP1) gene founder sequences and the level of Epstein-Barr virus (EBV) genome variability over time and across anatomic compartments by using virus genomes amplified directly from oropharyngeal wash specimens and peripheral blood B cells during acute infection and convalescence.
|
24429365 |
2014 |
|
Acute lymphocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
EBV LMP1 gene transcriptional activity was observed in a significant proportion of patients with acute lymphoblastic leukemia.
|
22264774 |
2012 |
|
Acute Promyelocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The Epstein-Barr virus (EBV) encoded Latent Membrane Protein 1 (LMP1) has been shown to increase the expression of promyelocytic leukemia protein (PML) and the immunofluorescent intensity of promyelocytic leukemia nuclear bodies (PML NBs).
|
21975125 |
2011 |
|
Addictive Behavior
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
The authors of this review have joined together to form an Addiction working group within the framework of the ENIGMA project, a meta-analytic approach to multisite genetic imaging data.
|
26822360 |
2016 |
|
Addictive Behavior
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study.
|
31746534 |
2019 |
|
Adenocarcinoma
|
0.040 |
GeneticVariation
|
group |
BEFREE |
To better understand the tumorigenic role of this LMP1 variant, we used PCR and sequencing to examine the LMP1 gene in 38 EBV-associated carcinomas (EBV-CAs) occurring in various organs (6 lung, 10 salivary gland, 5 sino-nasal, 16 gastric and 1 metastatic NPC), 55 reactive lymphoid tissues from tonsils (TON) and 67 EBV-negative tumours in various organs (22 adenolymphoma of salivary gland, 14 gastric and 31 colonic adenocarcinomas), where the virus was demonstrated in lymphocytes.
|
9219824 |
1997 |
|
Adenocarcinoma
|
0.040 |
Biomarker
|
group |
BEFREE |
In this study, we screened 113 gastric adenocarcinomas from low- and high-incidence regions (United States and Central America) for the presence of EBV using a battery quantitative real-time PCR (Q-PCR) assays targeting disparate segments of the EBV genome (BamH1W, EBNA1, LMP1, LMP2, BZLF1, EBER1) and histochemical stains targeting EBV-encoded RNA (EBER), the latent proteins LMP1 and LMP2, and the lytic proteins BMRF1 and BZLF1.
|
19002111 |
2009 |
|
Adenocarcinoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Because BARF1 exerts immortalizing effects on human epithelial cells in vitro and EBV-carrying gastric adenocarcinomas lack the expression of LMP1, the BARF1 gene might act as the viral oncogene in EBV-carrying gastric carcinomas.
|
10825150 |
2000 |
|
Adenocarcinoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
While 30 of 32 (94%) cases in differentiated nonkeratinizing carcinoma (NKC, WHO type 2) and 16 of 17 (94%) cases in undifferentiated carcinoma (UC, WHO type 3) showed EBERs expression, neither five cases of keratinizing squamous cell carcinoma (KSCC, WHO type 1) nor two cases of adenocarcinoma showed EBERs. bcl-2 protein was detected in 50 (89%) cases, but its expression did not depend on expression of LMP1. p53 protein was detected in 31 (55%) cases, and there was a correlation between expression of EBERs and p53 protein (P < 0.05) but not between LMP1 and p53 protein.
|
10231418 |
1999 |
|
Adenolymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
To better understand the tumorigenic role of this LMP1 variant, we used PCR and sequencing to examine the LMP1 gene in 38 EBV-associated carcinomas (EBV-CAs) occurring in various organs (6 lung, 10 salivary gland, 5 sino-nasal, 16 gastric and 1 metastatic NPC), 55 reactive lymphoid tissues from tonsils (TON) and 67 EBV-negative tumours in various organs (22 adenolymphoma of salivary gland, 14 gastric and 31 colonic adenocarcinomas), where the virus was demonstrated in lymphocytes.
|
9219824 |
1997 |
|
Adenolymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
EBER-RNA-ISH, mainly in the nasopharyngeal carcinoma cases, showed a more frequent positivity than the immunohistochemical reaction for LMP-1, however in case of the Warthin's tumor only the LMP-1 protein was expressed.
|
9761938 |
1998 |
|
Adult Anaplastic Large Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anaplastic large-cell lymphoma of T-cell type was consistently LMP 1-negative.
|
1318639 |
1992 |
|
Adult Burkitt Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
LMP promoter cat gene constructs were more active in a Burkitt's lymphoma cell line latently infected with the B95 EBV strain than in the same cells latently infected with the P3HR1 EBV strain.
|
2157069 |
1990 |
|
Adult Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, to identify targets of LMP1 that are regulated through PARP1, LMP1 was ectopically expressed in an EBV-negative Burkitt's lymphoma cell line.
|
30395643 |
2018 |
|
Adult Burkitt Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unusually high frequency of a 69-bp deletion within the carboxy terminus of the LMP-1 oncogene of Epstein-Barr virus detected in Burkitt's lymphoma of Turkish children.
|
9823956 |
1998 |
|
Adult Burkitt Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The EBV latent genes, latent membrane protein 1 (LMP1) and the EBV nuclear antigen 2 (EBNA2), were detected by immunohistochemistry in the Wiskott-Aldrich lymphoma but not in an EBV-positive Burkitt's lymphoma, implying that host immune factors could influence EBV gene expression.
|
8112728 |
1994 |
|
Adult Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD69 expression was upregulated in LMP-1‑expressing EBV-immortalized human B-cell lines and an EBV-positive Burkitt's lymphoma cell line.
|
23546309 |
2013 |
|
Adult Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have shown that Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) is uniquely able to up-regulate the expression of the peptide transporters (referred to as TAP-1 and TAP-2) and major histocompatibility complex (MHC) class I in Burkitt's lymphoma (BL) cell lines.
|
11799186 |
2002 |
|
Adult Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we report that clones of the BL line Mutu that differ in expression of LMP 1 also show a differential methylation pattern of the LMP 1 regulatory sequences: this region is hypomethylated in an LMP 1 expressing (group III) clone but methylated in a group I clone that does not express LMP 1.
|
8178450 |
1994 |
|
Adult Burkitt Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies of EBV-converted and stably transfected BL cell lines demonstrated that the EBV gene LMP-1 is neither necessary nor sufficient to block the TGF-beta1 response.
|
10811940 |
2000 |
|
Adult Burkitt Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The LMP1 and EBNA2 genes were transiently expressed from heterologous promoters in two human T-cell lines (HPB-ALL and Jurkat), two human cell lines of the myeloid lineage (K562 and U937), one type I Burkitt's lymphoma cell line (Rael) and in human primary T cells and B-cell chronic lymphocytic leukemia cells.
|
8093369 |
1993 |