PDLIM7, PDZ and LIM domain 7, 9260

N. diseases: 241; N. variants: 1
Disease: T-Cell Lymphoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE Transformation-associated EBV latent membrane protein 1 (LMP 1) was detected in 13 (6%) NHL, comprising 4 (4%) high-grade B-cell, 8 (10%) peripheral T-cell, and 1 non-B-cell, non-T-cell lymphomas. 1318639 1992
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 AlteredExpression disease BEFREE Therefore, we have investigated in T-cell lymphomas with similar morphology originating from different sites, ie, nose (n = 5; all pleomorphic small- or medium- and large-cell T-cell lymphomas [PTL]), skin (PTL, n = 6; anaplastic large-cell [ALCL], n = 11), gut (PTL, n = 8; ALCL, n = 4), and lung (PTL, n = 6), the presence of Epstein-Barr virus (EBV) at the DNA, RNA (EBER 1 and EBER 2), and protein level (LMP-1). 8123852 1994
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 AlteredExpression disease BEFREE Forty-two cases of Chinese T-cell lymphoma were studied for expression of Epstein-Barr virus (EBV) encoded RNA (EBER-1) and EBV latent membrane protein-1 (LMP-1) using in situ hybridization and immunohistochemistry, respectively. 8181803 1994
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE The virus shows a type II latency pattern (EBNA1+, LMP1+, EBNA2-) that seems to be similar to the EB virus associated nasal T cell lymphomas in oriental countries. 8666691 1996
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE These results indicate that EBV in Japanese non-Hodgkin's lymphomas is exclusively of type A with a specific deletion in LMP-1 and that it tends to be present in T cell lymphomas. 9260592 1997
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE Genetic studies showed that the virus detected in the T-cell lymphoma was indistinguishable, with respect to type and previously defined LMP-1 and EBNA-1 gene variations, from virus detected in the peripheral blood T cells 19 months earlier. 9490694 1998
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE All isolates without the LMP-1-Xho-1 site had a 30 bp deletion in the carboxy terminus of the LMP-1 gene, except for the isolate from a patient with angioimmunoblastic lymphadenophathy-like T-cell lymphoma in which a novel Nco-1 site was present in exon 1. 11002254 2000
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE A deletion within the LMP-1 gene was found in 4 of 25 cases (16%) of EBV-positive T-cell lymphomas, 4 of 10 cases (40%) of EBV-positive HD cases, and 2 of 13 specimens (15%) with amplified PCR products from 49 healthy individuals. 11039671 2000
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE Preferential localization of the Epstein-Barr virus (EBV) oncoprotein LMP-1 to nuclei in human T cells: implications for its role in the development of EBV genome-positive T-cell lymphomas. 11907247 2002
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE Comparative analysis of NK/T-cell lymphoma and peripheral T-cell lymphoma in Korea: Clinicopathological correlations and analysis of EBV strain type and 30-bp deletion variant LMP1. 14629296 2003
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 GeneticVariation disease BEFREE Although it is still not clear what the most specific and biologic variation of LMP1 gene in nasal NK/T-cell lymphoma is, the sequence data may be valuable on the study for pathogenesis of nasal NK/T-cell lymphoma and EBV molecular epidemiology. 16917737 2007
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 AlteredExpression disease BEFREE Clinical usefulness of serum EBV DNA levels of BamHI W and LMP1 for Nasal NK/T-cell lymphoma. 17385697 2007
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 AlteredExpression disease BEFREE Epstein-Barr virus BART9 miRNA modulates LMP1 levels and affects growth rate of nasal NK T cell lymphomas. 22102884 2011
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE Downregulation of miR-15a due to LMP1 promotes cell proliferation and predicts poor prognosis in nasal NK/T-cell lymphoma. 23963825 2014
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE LMP1 promotes nasal NK/T-cell lymphoma cell function by eIF4E via NF-κB pathway. 26397141 2015
CUI: C0079772
Disease: T-Cell Lymphoma
T-Cell Lymphoma 		0.100 Biomarker disease BEFREE Our data indicate that LMP1-IgG may provide a novel and promising therapeutic strategy for the treatment of LMP1-positive ENKTL. 28009988 2017