|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
EBV, a human gamma herpesvirus that contributes to the progression of a multitude of lymphomas and carcinomas in immunocompromised or genetically susceptible populations, packages its major oncoprotein, LMP1, into vesicles for secretion.
|
29212935 |
2018 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Currently, it is well established that onco-proteins of EBV (LMP1, LMP2A, and EBNA1) and high-risk HPVs (E5 and E6/E7) play an important role in the initiation and/or progression of several human carcinomas, including cervical, oral, and breast.
|
29765906 |
2018 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additionally, the expression of LMP1 onco-protein of EBV was found to be correlated with Fascin expression/overexpression in the majority of CRC tissue samples, which are intermediate/high grade invasive carcinomas.
|
28350509 |
2017 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Methylation of LMP1, 2A and 2B promoters mediates the silencing of LMP1, 2A and 2B in EBV-associated carcinomas and cell lines in varying degrees, and could be reactivated by demethylation agent and thus may contribute to the therapy of EBVaGCs.
|
27026080 |
2016 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Epstein-Barr virus (EBV) causes human lymphoid malignancies, and the EBV product latent membrane protein 1 (LMP1) has been identified as an oncogene in epithelial carcinomas such as nasopharyngeal carcinoma (NPC).
|
25745994 |
2015 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this prospective study, 32 paraffin-embedded tissues of various head and neck carcinomas and 20 normal tonsil specimens were examined for the presence of LMP-1 gene, using polymerase chain reaction.
|
19239950 |
2009 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Fifty-one (92.7%) of 55 EBV-positive carcinomas demonstrated the 30-bp deletion in LMP1 gene, and 53 (96.4%) of 55 cases were type 1 for EBNA2 and EBNA3B genes.
|
15014022 |
2004 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The study shows that the presence of LMP-1 gene detected by polymerase chain reaction in the tumor cell is only significantly associated with tumor located in the nasopharynx, implying that Epstein-Barr virus plays a trifling role in the tumorigenesis of carcinomas arising from other head and neck locations.
|
12782821 |
2003 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas.
|
12740914 |
2003 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Because BARF1 exerts immortalizing effects on human epithelial cells in vitro and EBV-carrying gastric adenocarcinomas lack the expression of LMP1, the BARF1 gene might act as the viral oncogene in EBV-carrying gastric carcinomas.
|
10825150 |
2000 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To elucidate the biological effects of LMP1 and the significance of its restricted expression in EBV-associated gastric carcinomas, the LMP1 gene was transferred into EBV-negative gastric carcinoma cell lines (SCM1 and TMC1) and into EBV-negative nasopharyngeal carcinoma (NPC) cells (HONE-1) as a control.
|
9422524 |
1998 |