|
Childhood Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, EBV-positive and -negative HL cases express survival, but not death signals of ER stress at similar levels and EBV-LMP1 transfection increases expression of survival signals in HL cell lines.
|
31699300 |
2020 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a HL tissue microarray, 96% of the CD137-positive HL cases stained positive for LMP1.
|
31058559 |
2019 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that CD63 is a critical player in LMP1 exosomal trafficking and LMP1-mediated enhancement of exosome production and may play further roles in limiting downstream LMP1 signaling.<b>IMPORTANCE</b> EBV is a ubiquitous gamma herpesvirus linked to malignancies such as nasopharyngeal carcinoma, Burkitt's lymphoma, and Hodgkin's lymphoma.
|
27974566 |
2017 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
LMP1 expression was found in 68.1% (45/66) of cases of Hodgkin lymphoma.
|
28427406 |
2017 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
LMP1 and Dynamic Progressive Telomere Dysfunction: A Major Culprit in EBV-Associated Hodgkin's Lymphoma.
|
28654015 |
2017 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunostaining of HL samples (n = 104) showed that expression of MIP-1α, MIP-1β and IL-13 correlated with EBV infection and LMP1 expression.
|
27632954 |
2017 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To assess the consequences of permanent latent membrane protein 1 (LMP1) expression as observed in tumor cells of Epstein-Barr virus (EBV) -associated HL, we analyzed 3-dimensional (3D) telomere dynamics and measured the expression of shelterin proteins at the transcriptional and translational level and their topographic distribution in the EBV-negative Burkitt cell line BJAB stably transfected with an inducible LMP1 system.
|
25568351 |
2015 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, we measured that all LMP1 proteins greatly impacted the cell cycle progression, triggering a reduction in the number of cells in S-phase and an accumulation of cells in the G2/M phase compared to the HL-non induced cells.
|
24886620 |
2014 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To further explore the definite rate in China, three methods, including immunohistochemistry for EBV latent membrane protein 1 (LMP1), in situ hybridization (ISH) for EBV-encoded RNA (EBER)-1 and polymerase chain reaction (PCR) for EBV BamHI‑W fragment, were employed to detect EBV in 59 cases of HL in China using paraffin-embedded tissue samples.
|
23128841 |
2013 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this issue of Blood, Cader et al show that tumor microenvironment promotes Epstein-Barr virus (EBV)-driven lymphomagenesis in Hodgkin lymphoma by a novel pathway involving latent membrane protein 1 (LMP1) and discoidin domain receptor 1 (DDR1), which is activated by collagen(s) and contributes to the survival of Reed-Sternberg (RS) cells.
|
24357706 |
2013 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
KDM6B is over-expressed in primary HL and induced by the EBV oncogene, latent membrane protein (LMP1) in GC B cells, the presumptive progenitors of HL.
|
21242977 |
2011 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
|
20876453 |
2011 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Both H cells and RS cells of two EBV-negative HL cases analyzed in parallel showed 3D telomere patterns identical to those of LMP1-expressing cases.
|
20142802 |
2010 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In vitro, EBV-LMP1 increased cytoplasmic cyclin A expression and multinucleation in an HL cell line.
|
19864233 |
2009 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gene expression profiling revealed that LMP1 induced in GC B cells transcriptional changes characteristic of Hodgkin's lymphoma cell lines.
|
18566961 |
2008 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show here that Bmi-1 and LMP1 down-regulate the ataxia telangiectasia-mutated (ATM) tumor suppressor and conclude that Bmi-1 contributes to LMP1-induced oncogenesis in HL.
|
17148591 |
2007 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggest a pathogenic role for LMP1 del30 variants in Hodgkin's lymphoma from South America and point to particular virus-host molecular mechanisms, such as genomic instability in LMP1 carboxy-terminus, leading to enhanced production and selection of these deletion variants.
|
17854036 |
2007 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously reported that exposure to CD40 ligand and IL-4 could induce LMP-1 in an in vitro EBV-infected Hodgkin lymphoma-derived cell line, which expressed only EBNA-1.
|
16332968 |
2006 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Coexpression of major histocompatibility complex class I and LMP1 in Epstein-Barr virus-positive Hodgkin's lymphoma in a pediatric age group.
|
16276512 |
2005 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
EBV encodes several latent genes, among them latent membrane protein 1 (LMP1) and LMP2A, which are regularly expressed in EBV-positive Hodgkin lymphoma and posttransplantation lymphomas.
|
16076866 |
2005 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The prognostic value of the expression of Bcl-2, p53 and LMP-1 in patients with Hodgkin's lymphoma.
|
16109607 |
2005 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four hematopathologists independently interpreted EBV-encoded RNA (EBER) and latent membrane protein 1 (LMP1) histochemical stains from 40 cases of Hodgkin lymphoma and then reviewed the stains as a group to resolve discrepancies and to develop interpretation guidelines.
|
11863222 |
2002 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The latent membrane protein LMP1 of Epstein-Barr virus (EBV) is often present in EBV-associated malignancies including nasopharyngeal carcinoma and Hodgkin's lymphoma.
|
10623751 |
2000 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Isolation and analysis of two strongly transforming isoforms of the Epstein-Barr-Virus(EBV)-encoded latent membrane protein-1 (LMP1) from a single Hodgkin's lymphoma.
|
9537580 |
1998 |
|
Childhood Hodgkin Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
LMP1 is present in the majority of nasopharyngeal carcinoma tumor cells and in Reed-Sternberg cells from Hodgkin's lymphoma, in which the only EBV nuclear antigen detected is EBNA1.
|
9406991 |
1997 |