HELB, DNA helicase B, 92797

N. diseases: 6; N. variants: 2
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.010 Biomarker disease BEFREE It was found that, in human melanoma A375 cells, 3,4-DHB is easily converted to its <i>ortho</i>-quinone via copper-containing tyrosinase-mediated two-electron oxidation along with generation of reactive oxygen species (ROS) derived from the oxidation; the resulting <i>ortho</i>-quinone and ROS are responsible for its ability to sensitize the cisplatin-resistant cells by inhibiting GST, followed by induction of apoptosis in an ASK1-JNK/p38 signaling cascade and mitochondria-dependent pathway. 31339696 2019