|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we assess the role of presepsin, which is a CD-14 polypeptide, and procalcitonin which has for some time been the inflammatory marker of choice in sepsis.
|
31523578 |
2019 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, monocyte CD64 and CD14 expression was unaltered in sepsis and was not associated with mortality risk.
|
31584643 |
2019 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Presepsin (PSEP: soluble CD14 subtype) is produced from bacteria-stimulated monocytes or neutrophils, thus recognized as a biomarker of sepsis.
|
29239264 |
2018 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among serum biomarkers, an emerging molecule is presepsin, the soluble fraction of CD14, recently described in other settings as a powerful diagnostic tool to detect sepsis at different degrees of severity.
|
29251000 |
2018 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to determine the signaling pathway of TLR activation-induced CD14 expression in models of polymicrobial sepsis and in peritoneal macrophages.
|
28562479 |
2018 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This analysis was aimed to determine whether the CD14-159C/T polymorphism confers susceptibility to sepsis or is associated with increased risk of death from sepsis.
|
28122493 |
2017 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
<i>Escherichia coli, Staphylococcus aureus,</i> and <i>Streptococcus agalactiae</i> were the main bacterial strains causing neonatal sepsis, while postnatal age was an independent risk factor for the onset of disease. sCD14-ST could be a potential useful diagnostic marker for pediatric sepsis.
|
28758124 |
2017 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Significant associations with SIRS and sepsis were found for CD14/HLA-DR expression and monocyte and polymorphonuclear cell levels of HSP70 and 90.
|
28119177 |
2017 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, simultaneous targeting of CD14 and factor XIa improves survival in the rabbit endotoxemia and sepsis models and represents a promising approach for the treatment of severe sepsis.
|
28249709 |
2017 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we analyzed the anti-inflammatory efficacy of the pheophytin-b on both RAW 264.7 murine macrophage and purified human CD14⁺ monocytes stimulated with lipopolysaccharide (LPS) and elucidated the mechanisms by analyzing the cell signaling pathways known to be activated in sepsis.
|
29211014 |
2017 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, CD14 is an attractive target for development of sepsis therapies, and several monoclonal anti-CD14 antibodies have been reported.
|
28322834 |
2017 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The complement system and the Toll-like (TLR) co-receptor CD14 play important roles in innate immunity and sepsis.
|
26241501 |
2015 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Organ inflammation in porcine Escherichia coli sepsis is markedly attenuated by combined inhibition of C5 and CD14.
|
25956456 |
2015 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we hypothesized that the strong pro-inflammatory response induced by the TT genotype of CD14 rs2569190 may have a beneficial effect on survival (30-day) in patients with sepsis.
|
26020644 |
2015 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rs11536889 polymorphism in TLR4 and rs2563298 polymorphism in CD14 were significantly associated with the risk of sepsis when compared to the control group.
|
25394369 |
2014 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, there was borderline association between CD14-159C/T and sepsis mortality under the dominant genetic model (OR = 1.44, 95%CI = 0.98-2.11, P = 0.06).
|
23990939 |
2013 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A receptor for LPS of Brucella and important innate immune molecule, CD14, has been implicated in the initiation of the inflammatory response to sepsis.
|
22770519 |
2012 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to determine whether distributions of tumor necrosis factor (TNF)-α(308), interleukin (IL)-10(1082), CD14(159), and IL-1ra gene intron 2 genotypes in critically ill patients are associated with outcome, underlying cause of sepsis, and type of microorganism.
|
20163933 |
2010 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the possible functional significance of both the G-1145A and T-159C polymorphisms in the CD14 promoter and their association with organ dysfunction and sepsis in adult trauma patients.
|
18596635 |
2008 |
|
Sepsis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that the -260TT CD14 genotype is associated with higher monocyte mCD14, but not sCD14 expression, and that in the first 24 h after sepsis diagnosis, both monocyte mCD14 density and sCD14 levels are elevated, similarly to what is observed in vitro upon challenge with LPS.
|
18991094 |
2008 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A potential (although untested) mechanism for our observation is that reduced signaling through CD14/toll-like receptor 4 in response to challenge by gram-negative bacteria after burns results in a blunted innate immune response and subsequent increased likelihood for systemic infection and death.
|
17304102 |
2007 |
|
Sepsis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Candidate genes for asthma and allergic diseases co-associated with sepsis including innate immunity receptors and related molecules (CD14, TLR4 and AOAH) and novel genes such as MYLK provide good examples of pleitropic effects of innate immunity genes, where variants conferring risk to specific traits (i.e. sepsis) under one set of genetic and environmental circumstances confer a reduced risk in a different (but possibly related) clinical outcome (i.e. allergic asthma), and support the 'common variant/multiple disease' hypothesis.
|
17989521 |
2007 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that CD14-159 C/T polymorphism might partly explain the difference in predisposition to develop complications of infectious diseases in different patients and may provide a therapeutic target for sepsis intervention strategies.
|
17515856 |
2007 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A mutant CD14 can produce a reduced signal in response to infection, as a result of which an adequate inflammatory innate response is not induced, leading to a systemic infection.
|
16509825 |
2006 |
|
Sepsis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants.
|
16611358 |
2006 |