|
Malignant neoplasm of stomach
|
0.100 |
Biomarker
|
disease |
BEFREE |
The correlations between KLF4 and PODXL was determined in GC tissues microarray and fresh GC tissues, and the molecular regulatory mechanism between KLF4 and PODXL was explored in vitro.
|
29748877 |
2019 |
|
Malignant neoplasm of stomach
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transcription factor KLF4 modulates microRNA-106a that targets Smad7 in gastric cancer.
|
31146975 |
2019 |
|
Malignant neoplasm of stomach
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the nature of the interactions between CagA and KLF4 in GC development has not been elucidated.
|
31162747 |
2019 |
|
Malignant neoplasm of stomach
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It was demonstrated that iASPP was upregulated and KLF4 was downregulated in GC cell lines.
|
29849786 |
2018 |
|
Malignant neoplasm of stomach
|
0.100 |
Biomarker
|
disease |
BEFREE |
KLF4-mediated inhibition of gastric cancer cell invasion was reversed by upregulation of STK33 expression.<b>Conclusions:</b> STK33 has pro-tumor function and is a critical downstream mediator of KLF4 in gastric cancer.
|
29367428 |
2018 |
|
Malignant neoplasm of stomach
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, this study demonstrated, for the first time, that the SNHG5/miR-32/KLF4 axis functions as an important player in GC cell migration and potentially contributes to the improvement of GC diagnosis and therapy.-Zhao, L., Han, T., Li, Y., Sun, J., Zhang, S., Liu, Y., Shan, B., Zheng D., Shi, J.
|
27871067 |
2017 |
|
Malignant neoplasm of stomach
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, miRNA target databases and luciferase reporter assay confirmed that Krüppel-like Factor-4 (<i>KLF4</i>) was a direct target of miR-103 in GC, and there was a significant inverse correlation between miR-103 and <i>KLF4</i> expression in GC tissues.
|
28445396 |
2017 |
|
Malignant neoplasm of stomach
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prognostic significance of KLF4 expression in gastric cancer.
|
28356964 |
2017 |
|
Malignant neoplasm of stomach
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we confirmed that LINC00673 promoted cell proliferation and invasion by partly repressing KLF4 expression in GC.
|
29221147 |
2017 |
|
Malignant neoplasm of stomach
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that miR-10b was upregulated in GC and may have a key role in GC pathogenesis and development through the downregulation of its target gene KLF4.
|
26191201 |
2015 |
|
Malignant neoplasm of stomach
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that KLF4 could be used as a potential therapeutic target; curcumin could act as an auxiliary and provide a promising therapeutic strategy in stomach cancer.
|
25292057 |
2014 |
|
Malignant neoplasm of stomach
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we investigated the expression of KLF4 in gastric cancers and its correlation with clinicopathological parameters and overall survival.
|
24105022 |
2013 |
|
Malignant neoplasm of stomach
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the potential interaction between KLF4 and β-catenin during gastric cancer development is unknown.
|
22407433 |
2012 |
|
Malignant neoplasm of stomach
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
KLF4 expression specifically stimulated human ghrelin-promoter activity in a dose-dependent manner in human gastric-cancer AGS cells.
|
19327128 |
2009 |
|
Malignant neoplasm of stomach
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In addition, promoter hypermethylation of the KLF4 gene was observed in only two gastric cancers.
|
17614846 |
2007 |
|
Malignant neoplasm of stomach
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Collectively, our data provide first clinical and casual evidence and potential mechanism that the alteration of KLF4 expression plays a critical role in gastric cancer development and progression.
|
15805274 |
2005 |