Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings suggest that in Klf4-null cells, decreased Bnip3 expression impairs mitophagy and is associated with increased mitochondrial ROS production after mitochondrial damage, providing a rationale for their genomic instability and supports a tumor suppressive role for KLF4 in certain tumors as previously observed.
|
31839365 |
2020 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Krüppel-Like Factor 4 (KLF4) is a member of the KLF transcription factor family, and evidence suggests that KLF4 is either an oncogene or a tumor suppressor.
|
31040909 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we found that KLF4 played as a tumor-promoting gene in NPC, and could be mediated by PLK1.
|
31281496 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results showed that CDK7/9 were highly expressed in UM cells, and SNS-032 significantly suppressed the cellular proliferation, induced apoptosis, and inhibited the outgrowth of xenografted UM cells and PDX tumors in NOD-SCID mice, repressed the cancer stem-like cell (CSC) properties through transcriptional inhibition of stemness-related protein Krüppel-like factor 4 (KLF4), inhibited the invasive phonotypes of UM cells through matrix metalloproteinase 9 (MMP9).
|
31526394 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we report that Krüppel-like factor 4 (KLF4) promotes disease progression in a murine model of chronic myeloid leukemia (CML)-like myeloproliferative neoplasia by repressing an inhibitory mechanism of preservation in leukemia stem/progenitor cells with leukemia-initiating capacity.
|
31515251 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, glibenclamide upregulated the expression of the tumor suppressor Krüppel-like factor 4 (KLF4), and silencing KLF4 partially reversed the inhibitory effect of glibenclamide on cell growth, EMT, and migration.
|
31341030 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Upon AOM and DSS treatment, KLF4 expression was progressively lost in colonic tissues of <i>Klf4<sup>fl/fl</sup></i> mice during tumor development.
|
30108164 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KLF4 suppresses the tumor activity of cutaneous squamous cell carcinoma (SCC) cells via the regulation of SMAD signaling and SOX2 expression.
|
31284949 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Besides, we proved that miR-103 exerted its function by adjusting the expression level of the tumor-suppressor gene KLF4, and the expression level was negatively associated with miR-103.
|
31119790 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
KLF4 was identified to be primarily expressed in the cytoplasm of non‑tumor prostate tissues.
|
30747213 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, KLF4 null cells proliferate rapidly, forming large, invasive, and osteolytic tumors when injected into mouse femurs, whereas KLF4 re-expression immediately after their intra-femoral inoculation blocks tumor development and preserves a normal bone architecture.
|
31239516 |
2019 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Among the tumors from the KLF4-mutated group, almost half were petroclival meningiomas.
|
31177425 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, our data revealed that KLF4 can facilitate the transcription of tumor suppressor TIMP3 by directly binding to the TIMP3 promoter.
|
31748695 |
2019 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
However, the underlying regulatory mechanisms associated with the Klf4 gene as a tumor suppressor in HCC remain unclear. microRNAs (miRNAs or miRs) are a series of small non‑coding RNAs that serve a vital role in regulating gene expression via their influence on protein translation and the associated degradation of mRNA.
|
30664155 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this pilot study, we compared the combined expression of PTTG1 with KLF4 and OCT4 in seminoma, in order to validate our hypotesis that PTTG1 marks a specific population of stem cells in neoplastic tissue, strictly related with tumor.
|
31572301 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Kruppel-like factor 4 (Klf4) was reported to have both tumor suppressive and oncogenic roles on tumorigenesis, which is depend on its subcellular localization.
|
29665649 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, KLF4 inhibitor Kenpaullone sensitizes breast cancer cells and xenograft tumors to Paclitaxel and improves therapeutic effects.
|
30038266 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Krüppel-like factor 4 (KLF4), a member of the KLF family of zinc finger transcription factors, has been identified as a tumor suppressor gene in a variety of tumors.
|
29587259 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The previous study found that oncogene Klf4 played a role of tumor suppressor in the nasopharyngeal cytoplasm.
|
29973197 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accumulating studies have demonstrated that Krüppel-like factor 4 (KLF4) can act as a tumor suppressor or oncogene in the carcinogenesis of diverse cancers.
|
29940144 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cross-species analysis revealed a shared increase in human lung adenocarcinoma markers including Nkx2.1 and Napsa as well as alterations in a subset of genes with oncogenic and tumor suppressive properties such as Aurka, Ret, Klf4 and Lats2.
|
30412601 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that reducing expression or activity of the Klf4 transcription factor in tumor myeloid cells may contribute to prostate cancer therapy.
|
29324844 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Significantly, As exposure-reduced H3K27ac and H3K4me1 inhibited the expression of genes including EP300 itself and Kruppel Like Factor 4(Klf4) that both are tumor suppressor genes.
|
30130555 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We observed that A375 (but not BLM) cells are able to form melanospheres and show CSCs traits: expression of the pluripotency markers SOX2 and KLF4, higher invasiveness and tumor formation capability in vivo with respect to parental adherent cells.
|
29330434 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KLF4 and its downstream targets make up a gene signature that identifies indolent tumors and predicts recurrence-free survival.
|
30540935 |
2018 |