SLIT2, slit guidance ligand 2, 9353

N. diseases: 177; N. variants: 3
Disease: Cakut ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1968949
Disease: Cakut
Cakut 		0.020 AlteredExpression disease BEFREE Slit2/Robo2 and Spry1 expression levels were decreased, Ret expression was increased, and downstream p-Akt activity enhanced with apoptosis abnormal in ureteric bud tissue, which may be the mechanisms that intrauterine low-protein diet causes increased incidence of CAKUT in offspring. 30987821 2019
CUI: C1968949
Disease: Cakut
Cakut 		0.020 GeneticVariation disease BEFREE We then examined the pathway-derived candidate gene SLIT2 for mutations in cohort of 749 individuals with CAKUT and we identified 3 unrelated individuals with heterozygous mutations. 26026792 2015