SLIT2, slit guidance ligand 2, 9353

N. diseases: 177; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 Biomarker disease BEFREE This study is to investigate the methylation status of multiple tumor suppressor 1 (p16), secreted glycoprotein 2 (SLIT2), scavenger receptor class A, member 5 putative (SCARA5), and human runt-related transcription factor 3 (Runx3) genes in the peripheral blood of hepatocellular carcinoma (HCC).This is a case-control study. 29019900 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 AlteredExpression disease BEFREE Large-scale data mining of the Oncomine database has revealed heterogeneous expression of Slit2 in HCC. 27176045 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 Biomarker disease BEFREE Thus, SLIT2 may be useful as a therapeutic target in the treatment of HCC. 19100240 2009
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 Biomarker disease CTD_human Thus, SLIT2 may be useful as a therapeutic target in the treatment of HCC. 19100240 2009
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.330 PosttranslationalModification disease LHGDN Thus, SLIT2 may be useful as a therapeutic target in the treatment of HCC. 19100240 2009
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.310 Biomarker disease CTD_human Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. 22941188 2012
CUI: C0014556
Disease: Epilepsy, Temporal Lobe
Epilepsy, Temporal Lobe 		0.310 Biomarker disease CTD_human Slit2 expression was significantly higher in TLE patients as compared with the controls. 20153733 2010
CUI: C0014556
Disease: Epilepsy, Temporal Lobe
Epilepsy, Temporal Lobe 		0.310 AlteredExpression disease BEFREE Slit2 expression was significantly higher in TLE patients as compared with the controls. 20153733 2010
CUI: C0149925
Disease: Small cell carcinoma of lung
Small cell carcinoma of lung 		0.310 PosttranslationalModification disease BEFREE SLIT2 promoter methylation was detected in 59% of breast cancer, 77% of non-small cell lung cancer, and 55% of small cell lung cancer cell lines. 12384551 2002
CUI: C0014558
Disease: Uncinate Epilepsy
Uncinate Epilepsy 		0.300 Biomarker disease CTD_human Abnormal expression and spatiotemporal change of Slit2 in neurons and astrocytes in temporal lobe epileptic foci: A study of epileptic patients and experimental animals. 20153733 2010
CUI: C0393672
Disease: Epilepsy, Benign Psychomotor, Childhood
Epilepsy, Benign Psychomotor, Childhood 		0.300 Biomarker disease CTD_human Abnormal expression and spatiotemporal change of Slit2 in neurons and astrocytes in temporal lobe epileptic foci: A study of epileptic patients and experimental animals. 20153733 2010
CUI: C0393682
Disease: Epilepsy, Lateral Temporal
Epilepsy, Lateral Temporal 		0.300 Biomarker disease CTD_human Abnormal expression and spatiotemporal change of Slit2 in neurons and astrocytes in temporal lobe epileptic foci: A study of epileptic patients and experimental animals. 20153733 2010
CUI: C1332309
Disease: Anti-Basement Membrane Glomerulonephritis
Anti-Basement Membrane Glomerulonephritis 		0.200 Biomarker disease RGD Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis. 15215188 2004
CUI: C0008780
Disease: Ciliary Motility Disorders
Ciliary Motility Disorders 		0.200 Biomarker group MGD
CUI: C0022521
Disease: Kartagener Syndrome
Kartagener Syndrome 		0.200 Biomarker disease MGD
CUI: C0022679
Disease: Cystic kidney
Cystic kidney 		0.200 Biomarker disease MGD
CUI: C1415817
Disease: HETEROTAXY, VISCERAL, 2, AUTOSOMAL
HETEROTAXY, VISCERAL, 2, AUTOSOMAL 		0.200 Biomarker disease MGD
CUI: C1844020
Disease: HETEROTAXY, VISCERAL, 1, X-LINKED
HETEROTAXY, VISCERAL, 1, X-LINKED 		0.200 Biomarker disease MGD
CUI: C1853444
Disease: Heterotaxy, Visceral, 3, Autosomal
Heterotaxy, Visceral, 3, Autosomal 		0.200 Biomarker disease MGD
CUI: C3151057
Disease: HETEROTAXY, VISCERAL, 4, AUTOSOMAL
HETEROTAXY, VISCERAL, 4, AUTOSOMAL 		0.200 Biomarker disease MGD
CUI: C3151867
Disease: CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 1, X-LINKED
CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 1, X-LINKED 		0.200 Biomarker disease MGD
CUI: C3178805
Disease: Heterotaxy Syndrome
Heterotaxy Syndrome 		0.200 Biomarker disease MGD
CUI: C3553676
Disease: HETEROTAXY, VISCERAL, 6, AUTOSOMAL
HETEROTAXY, VISCERAL, 6, AUTOSOMAL 		0.200 Biomarker disease MGD
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 Biomarker disease BEFREE SLIT2 can induce BC cell motility and chemotaxis, but the latter requires the presence of heparin. 30842157 2019
CUI: C0015944
Disease: Fetal Membranes, Premature Rupture
Fetal Membranes, Premature Rupture 		0.100 GeneticVariation phenotype GWASCAT Risk of spontaneous preterm birth and fetal growth associates with fetal SLIT2. 31194736 2019