|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several pathogenic mechanisms such as inflammation-related endothelial dysfunction, mineral metabolism disorders, activation of the renin-angiotensin system, reduction of nitric oxide, lipid disorders, and the fibroblast growth factor 23-klotho axis are involved in the pathogenesis of atherosclerosis and arteriosclerosis, including VC.
|
31801144 |
2020 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In predialysis stage 3-5 diabetic and nondiabetic CKD patients, CAVI levels and its relation to atherosclerosis-associated risk factors including monocyte-chemoattractant protein-1 (MCP-1), sclerostin, fibroblast growth factor-23 (FGF-23), Klotho, and 25-OH vitamin D were determined.
|
31773386 |
2020 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most notably, Klotho deficiency is associated with a phenotype comprising organ manifestations accompanying aging including atherosclerosis and cognitive impairment.
|
31055648 |
2019 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genotyping of 11 SNPs of the Klotho gene was performed and its association with atheromatosis progression was determined by multivariate logistic regression.
|
30010839 |
2019 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Circulating α-Klotho Levels in Hemodialysis Patients and Their Relationship to Atherosclerosis.
|
30064142 |
2018 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most notably, Klotho deficiency is associated with a phenotype comprising organ manifestations accompanying aging including atherosclerosis and cognitive impairment.
|
29274997 |
2018 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Klotho, an anti-aging protein, has been reported to protect against atherosclerosis and ameliorate endothelial dysfunction in vivo.
|
28407763 |
2017 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we demonstrate that Klotho protein treatment can protect against IS-induced thrombosis and atherosclerosis in <i>apoE</i><sup>-/-</sup> mice.
|
28264799 |
2017 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study indicates an inverse interrelationship between inflammation and Klotho in atherosclerosis.
|
28963437 |
2017 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Klotho is a hormone secreted into human cerebrospinal fluid (CSF), plasma and urine that promotes longevity and influences the onset of several premature senescent phenotypes in mice and humans, including atherosclerosis, cardiovascular disease, stroke and osteoporosis.
|
27576165 |
2016 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role in atherosclerosis and cardiovascular disease of klotho, an aging process-related gene, has been highlighted.
|
23993164 |
2013 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Klotho, a gene related to aging, has been reported to play a role in atherosclerosis and endothelial dysfunction.
|
23147162 |
2012 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Klotho gene might be a candidate gene of atherosclerosis in some populations but not in Iranian population.
|
22045427 |
2011 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous studies suggest that klotho gene polymorphisms may be associated with atherosclerosis, but did not assess the relationship between klotho gene polymorphisms and atherosclerosis parameters such as carotid artery intima-media thickness (IMT).
|
20345435 |
2010 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Experimental studies have demonstrated KLOTHO gene polymorphism might be associated with vascular atherosclerosis and calcification.
|
19246844 |
2009 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the other hand, klotho is a putative antiaging gene identified in 1997 when a particular mouse strain, created by random insertion mutagenesis, was found to be short-lived and displayed premature atherosclerosis, osteopenia, skin atrophy, pulmonary emphysema, hyperphosphatemia, hypercalcemia, and high serum calcitriol levels.
|
19121771 |
2009 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Klotho-disrupted mice exhibit atherosclerosis and endothelial dysfunction, which led us to investigate the effect of the Klotho protein on vascular inflammation, particularly adhesion molecule expression.
|
19367378 |
2009 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The klotho gene, originally identified by insertional mutagenesis in mice, suppresses multiple aging phenotypes, including atherosclerosis.
|
16579981 |
2006 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
These results infer the possibility of the KLOTHO gene being a candidate gene of atherosclerosis in humans, and further research on this topic needs to be done.
|
16979405 |
2006 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results infer the possibility of the KLOTHO gene being a candidate gene of atherosclerosis in humans, and further research on this topic needs to be done.
|
16979405 |
2006 |