|
Diabetic Nephropathy
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The aim of our study was to show the relationship between the levels of s-Klotho and tubular injury in patients with diabetic kidney disease (DKD), using as tubular injury marker the kidney injury molecule-1 (KIM-1).
|
30396700 |
2020 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Moreover, klotho attenuated diabetic nephropathy in db/db mice, which was also associated with inhibition of the Wnt/β-catenin pathway and RAAS.
|
30784349 |
2020 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
In summary, miR-199a-5p from HSA-stimulated HK-2 cell-derived EVs induces M1 polarization by targeting the Klotho/TLR4 pathway and further accelerates the progression of DKD.
|
31208912 |
2019 |
|
Diabetic Nephropathy
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
And Klotho gene deficiency enhances the phosphorylation of mammalian target of rapamycin (mTOR), resulting in exacerbating streptozotocin-stimulated diabetic glomerular injury and promoting the progression of early diabetic kidney disease (DKD).
|
29890551 |
2019 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Klotho inhibits PKCα/p66SHC-mediated podocyte injury in diabetic nephropathy.
|
31207271 |
2019 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Sustained Klotho delivery reduces serum phosphate in a model of diabetic nephropathy.
|
30605400 |
2019 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
These results also showed that klotho might be used as a unique molecular target for the treatment of diabetic nephropathy.
|
30668400 |
2019 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Effects of Pentoxifylline on Soluble Klotho Concentrations and Renal Tubular Cell Expression in Diabetic Kidney Disease.
|
29866645 |
2018 |
|
Diabetic Nephropathy
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Corrigendum: Atrasentan increased the expression of klotho by mediating miR-199b-5p and prevented renal tubular injury in diabetic nephropathy.
|
29623952 |
2018 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, the roles of P2X<sub>7</sub> and klotho in the progression of diabetic nephropathy are still unclear.
|
29541926 |
2018 |
|
Diabetic Nephropathy
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Vitamin D may have a valuable role in the renal protective effect from DN, this may occur via expression of its VDR, Klotho and blocking renin-angiotensin activation, so vitamin D should be considered as a target in renal prophylactic measures against DN.
|
29308676 |
2018 |
|
Diabetic Nephropathy
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Our study suggests that SDX may prevent the progression of DKD at the early stage by upregulating renal klotho expression, which inhibits the tubulointerstitial injury induced by oxidative stress.
|
28929120 |
2017 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Klotho can attenuate renal fibrosis in part by inhibiting TGF-β1/Smad3 signaling in DKD.
|
28411025 |
2017 |
|
Diabetic Nephropathy
|
0.300 |
Biomarker
|
disease |
BEFREE |
Treated the mice and HK-2 cells with atrasentan, and we then investigated whether and how miR-199b-5p and Klotho were involved in preventing renal tubular injury in DN.
|
26813039 |
2016 |
|
Diabetic Nephropathy
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We found that klotho protein overexpression attenuates renal hypertrophy and glomerular injury in this mouse model of diabetic nephropathy.
|
26586006 |
2016 |
|
Diabetic Nephropathy
|
0.300 |
Therapeutic
|
disease |
RGD |
Taken together, oral administration of TZD may improve STZ-induced diabetic nephropathy due to restoration of the expression of klotho axis through an increase in PPARγ expression without changing blood glucose in rats.
|
24136780 |
2014 |
|
Diabetic Nephropathy
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Thus, α-Klotho expression was decreased in distal convoluted tubules in diabetic nephropathy in humans and mice.
|
22217880 |
2012 |