KL, klotho, 9365

N. diseases: 332; N. variants: 20
Disease: Hyperinsulinism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.030 AlteredExpression disease BEFREE In aged animals, TG mice with Hap-I show increased expression of hAT1R and higher blood pressure (BP); suppression of antioxidant defenses (hemoxygenase, superoxide dismutase) and antiaging molecules (ATRAP, Klotho, Sirt3); increased expression of pro-inflammatory markers (IL-6, TNFα, CRP, NOX1); and increased insulin resistance. 30084918 2018
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.030 AlteredExpression disease BEFREE Increasing the full-length human Klotho levels has a positive effect on blood glucose through increasing insulin secretion. 26806457 2016
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.030 GeneticVariation disease BEFREE Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. 11016890 2000