|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
This study investigated whether autophagy plays a role in Klotho gene deficiency-induced arterial stiffening and hypertension.
|
31630227 |
2019 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Our results suggest that chronic intermittent hypoxia reduces the levels of klotho in OSA, which may contribute to the development of hypertension.
|
31094281 |
2019 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
VDD+AmB/LE rats also presented alterations in the PTH-Klotho-FGF-23 signaling axis, urinary concentrating defect and hypertension, probably due to an inappropriate activation of the renin-angiotensin-aldosterone system.
|
31295336 |
2019 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Placental and serum KL levels were significantly higher in the PE than in the controls and in women with chronic hypertension.
|
31446221 |
2019 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In conclusion, Klotho C1818T variant may be associated with a decreased risk of hypertension.
|
30547758 |
2018 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
The bone-derived hormone fibroblast growth factor-23 (FGF-23) activates complexes composed of FGF receptors (FGFRs), including FGFR1, and <i>α</i>-Klotho in the kidney distal tubule (DT), leading to increased sodium retention and hypertension.
|
28993502 |
2018 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
Experiments were performed to examine whether exogenous klotho protein supplementation ameliorates pressure natriuresis in early phase of hypertension, using stroke-prone spontaneously hypertensive rats (sp-SHR).
|
30354813 |
2018 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Overexpression of Klotho is shown to ameliorate medial calcification, endothelial dysfunction, and hypertension.
|
27693241 |
2017 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
FGF-23 (Z = 5.03; P < 0.001) and soluble α Klotho (Z = 5.61; P < 0.001) were higher in cirrhotics, and both were related to liver function, independently of serum creatinine FGF-23 levels were higher among alcoholics with diabetes (Z = 2.55; P = 0.011) or hypertension (Z = 2.56; P = 0.01), and increased body fat (ρ = 0.28; P = 0.022 for trunk fat), whereas α Klotho levels were higher in patients with LVH (Z = 2.17; P = 0.03) or atrial fibrillation (Z = 2.34; P = 0.019).
|
28651327 |
2017 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In the whole population and women, the relationship between the Klotho G-395A SNP and MetS might due to its influence on high blood pressure (OR 0.48, 95% CI 0.34 to 0.67; OR 0.47, 95% CI 0.31 to 0.71, respectively) and hypertriglyceridemia (OR 0.66, 95% CI 0.39 to 0.95; OR 0.54, 95% CI 0.31 to 0.98, respectively).
|
26880028 |
2016 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
Treatment with SRT1720 (15 mg/kg/d, IP), a specific SIRT1 activator, abolished Klotho deficiency-induced arterial stiffness and hypertension in KL<sup>+/-</sup> mice.
|
27620389 |
2016 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to analyze the placental expression and allele status of promoter region of Klotho in association with preeclampsia, which represents the most common hypertensive disease of pregnancy.
|
26972301 |
2016 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Subjects expressing the GA+AA genotype demonstrated a significantly lower risk of hypertension even after adjusting for age, gender, and other relevant risk factors compared to the population expressing the GG genotype (odds ratio, 0.68; 95% confidence interval: 0.49 to 0.95).The -395A allele of the KLOTHO gene may be a protective genetic factor for hypertension in the Chinese population.
|
26634510 |
2015 |
|
Hypertensive disease
|
0.300 |
Therapeutic
|
group |
RGD |
Fosinopril and valsartan intervention in gene expression of Klotho, MMP-9, TIMP-1, and PAI-1 in the kidney of spontaneously hypertensive rats.
|
21051829 |
2010 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Therefore, klotho SNP (rs650439) may influence on the progression of carotid atherosclerosis in patients with hypertension.
|
20345435 |
2010 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
RGD |
We further cloned rat klotho cDNA and investigated whether klotho mRNA expression in rat kidney is altered under pathological conditions such as hypertension, hyperlipidemia, renal failure, and inflammatory stress.
|
10892340 |
2000 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
We further cloned rat klotho cDNA and investigated whether klotho mRNA expression in rat kidney is altered under pathological conditions such as hypertension, hyperlipidemia, renal failure, and inflammatory stress.
|
10892340 |
2000 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
This is the first report showing the expression of the klotho gene in the kidney is regulated under sustained circulatory stress such as long-term hypertension, diabetes mellitus, and chronic renal failure.
|
9731228 |
1998 |