|
Kidney Failure, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Conclusion:</b> Neferine mitigated renal injury in AKI models, perhaps by suppressing the activation of NF-κB and upregulating the expression of Klotho.
|
31680971 |
2019 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
Urine Klotho may serve as an early biomarker for AKI and subsequent poor short-term renal outcome in patients undergoing cardiac surgery.
|
31315593 |
2019 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
To analyze the role of Klotho in sepsis-related organ dysfunction and AKI, we used a cecal ligation and puncture (CLP) model of sepsis in heterozygous Klotho-haploinsufficient mice and their wild-type littermates (CLP- Kl/+ and CLP-WT mice, respectively).
|
30516423 |
2019 |
|
Kidney Failure, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We review the pathophysiology, kinetics, and regulation of FGF23 and klotho in animal and human studies of AKI, and we discuss the challenges and opportunities involved in targeting FGF23 and klotho therapeutically.
|
30606408 |
2019 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study investigated the protective effects of melatonin (MT) against cisplatin (CP)-induced acute kidney injury in rats as well as its possible mechanism of action associated with anti-aging protein Klotho.
|
31039387 |
2019 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the role of <i>α</i>-klotho in acute heart injury and acute kidney injury with sepsis remains unknown.
|
31309036 |
2019 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
The protective effect of klotho against contrast-associated acute kidney injury via the antioxidative effect.
|
31411071 |
2019 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
We then transplanted Klotho-GFP-BMSCs into mice with AKI and investigated the therapeutic effect compared with that of sham-treated mice and GFP-BMSC-transplanted mice.
|
30358003 |
2018 |
|
Kidney Failure, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Renal Klotho expression in human sepsis-acute kidney injury and in mouse models of sepsis was significantly decreased and correlated with renal damage.
|
30239382 |
2018 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies in human samples further confirmed the Klotho deficiency and increased formation of RIP3 puncta in AKI kidneys.
|
29550818 |
2018 |
|
Kidney Failure, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recombinant KL alleviates renal dysfunction and restores renal KL expression in mice with sepsis-induced AKI, but the underlying mechanism may not be related to autophagy induction.
|
29497318 |
2018 |
|
Kidney Failure, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this review, we will discuss pathophysiology of IRI-induced acute kidney injury and its relation with klotho level in renal transplantation procedure.
|
29608890 |
2018 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results regarding the Klotho, CYR61 and YKL-40 biomarkers showed markedly equivocal performance in the previous studies and did not fulfill the expectations that these factors would form valid possible biomarkers for AKI.
|
27759760 |
2017 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hydrogen-Rich Saline Alleviates Kidney Fibrosis Following AKI and Retains Klotho Expression.
|
28848432 |
2017 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
This article reviews the current knowledge of αKlotho antioxidation in the lung in the setting of AKI as a model of circulating αKlotho deficiency, an under-recognized condition that weakens innate cytoprotective defenses and contributes to the dysfunction in distant organs.
|
28347910 |
2017 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since acute kidney injury (AKI) greatly escalates the risk of CKD development, we explored the effect of α-Klotho on prevention and treatment on post-AKI to CKD progression and cardiovascular disease.
|
28131398 |
2017 |
|
Kidney Failure, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Klotho levels were higher in AKI patients (567.6 ± 294.4 pg/mL, vs. 403.5 ± 152.5 pg/mL, p < 0.01) and females (463.0 ± 202.6 pg/mL vs. 387.6 ± 132.0 pg/mL, p < 0.01) and lower in ESRD patients than in healthy adults and patients with moderate CKD (368.3 ± 99.0 pg/mL vs. 468.1 ± 205.8, p < 0.01 and 368.3 ± 99.0 pg/mL vs. 498.7 ± 221.9, p < 0.01).
|
28157067 |
2017 |
|
Kidney Failure, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Klotho is down-regulated in acute kidney injury in native kidney; however, the modulation of Klotho in kidney transplantation has not been investigated.
|
26280899 |
2016 |
|
Kidney Failure, Acute
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Klotho has anti-aging and nephroprotective properties, and decreased Klotho levels may contribute to increase the risk of death, CKD progression, and AKI.
|
27760772 |
2016 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review focuses on the Klotho-FGF23 endocrine system that maintains phosphate (Pi) homeostasis, and discusses the mechanism of action and the potential contribution of Klotho deficiency to acute kidney injury (AKI), chronic kidney disease (CKD) and cancer.
|
22660551 |
2012 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, sensitive biologic markers of renal tubular injury in AKI are strongly needed.Hu et al. suggest that Klotho could be a novel biomarker and therapeutic target of ischemia-induced AKI.
|
21116272 |
2010 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rats with AKI given recombinant Klotho had higher Klotho protein, less kidney damage, and lower NGAL than rats with AKI given vehicle.
|
20861825 |
2010 |
|
Kidney Failure, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
Klotho reduces apoptosis in experimental ischaemic acute kidney injury via HSP-70.
|
19745103 |
2010 |