|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although numerous studies were performed on the role of the α-Klotho gene and protein in neoplasia, the data on α-Klotho protein expression in thyroid cancers are very scarce.
|
30699231 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Role of Klotho Protein in Tumor Genesis, Cancer Progression, and Prognosis in Patients with High-Grade Glioma.
|
31228703 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The in vivo activity of klotho and KL1 was examined using two models recapitulating development of tumors in the normal colonic environment of immune-competent mice.
|
30232408 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To assess the effect of KL1 on breast tumor cells metabolism, as KL1 possesses the tumor suppressor activity of klotho.
|
31507133 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, <i>KL</i> is downregulated in dedifferentiated liposarcomas (DDLPS) compared to well-differentiated tumors and adipose tissue.
|
30441794 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Klotho (KL) was originally characterized as an aging suppressor gene, and has been identified as a tumor suppressor gene in a variety of cancers, including colorectal cancer.
|
29884183 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of KLγ with siRNA led to a dramatic change in tumor growth and suggested that KLγ had effects on tumor growth, including promotion of cell proliferation, inhibition of apoptosis, and enhancement of the epithelial-mesenchymal transition.
|
29731962 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The anti-aging factor, klotho has been identified as a tumor suppressor in various human cancers, including lung cancer.
|
29948618 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KLB interacts with FGFR4 to induce apoptosis and inhibit the proliferation of hepatoma cells, and KLA has been demonstrated to be a tumor suppressor in human breast cancer; however, little is known regarding the role of KLB in breast cancer.
|
29344186 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Enforced expression of Klotho could significantly induce cell apoptosis and inhibit tumor growth in DLBCL.
|
28153033 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data indicated that Klotho acts as a tumor suppressor via inhibiting IGF-1R signaling, thus suppressing the viability and promoting apoptosis in T‑cell lymphoma.
|
28656297 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings suggest that overexpression of Klotho may suppress tumor growth in animal models.
|
28259911 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The Klotho promoter gene is generally hypermethylated in cancer, and overexpression or supplementation of Klotho has been found to inhibit tumor growth in various animal models.
|
28709936 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Preliminary studies also suggest that Klotho possesses tumor suppressor properties.
|
27576165 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Klotho expression was high in all endocervical and exocervical normal tissues adjacent to tumour.
|
26209729 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The Role of Alpha-Klotho as a Universal Tumor Suppressor.
|
27125743 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular carcinoma.
|
26237271 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Knockdown of Klotho gene expression significantly decreased apoptosis, increased invasion in melanoma cells, and inhibited xenograft A375 tumor growth.
|
27779100 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Data from a wide array of malignancies indicate klotho as a tumor suppressor; however, the structure-function relationships governing its tumor suppressor activities have not been deciphered.
|
26113466 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In order to shed some light into the molecular mechanisms underlying breast cancer in the Saudi community, we identified KLOTHO (KL) as a tumor-specific methylated gene using genome-wide methylation analysis of primary breast tumors utilizing the MBD-seq approach.
|
26152288 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
And, a significant inverse correlation between the level of miR-10b and klotho was observed, which has been demonstrated to be a novel tumor suppressor gene.
|
25988292 |
2015 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
In conclusion, klotho is silenced in a substantial subset of the tumors and restoring its expression slows growth of EOC cells and inhibits major signaling pathways.
|
25827069 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, Klotho is also identified as a tumor suppressor gene in variety of tumors; however, the potential role and the antitumor mechanism remain unclarified in liver cancers.
|
26499380 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Tumor tissues (73.9 %) had concurrent methylation of two or more genes, with the most frequent combination as KLOTHO and IGFBP7 (53.8 %).
|
24852431 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Klotho is a tumor suppressor whose expression in PDAC correlated with progression and prognosis of PDAC.
|
24745611 |
2014 |