KL, klotho, 9365

N. diseases: 332; N. variants: 20
Disease: Mental deterioration ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		0.050 Biomarker phenotype BEFREE Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aβ burden and APOE ε4-driven cognitive decline in preclinical AD. 30716541 2019
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		0.050 AlteredExpression phenotype BEFREE A reduced blood α-Klotho level was correlated with grading of cerebral DWMLs and was accompanied by cognitive decline as an independent risk factor. 29154273 2018
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		0.050 AlteredExpression phenotype BEFREE Our current study indicates that klotho upregulation may be a neuroprotective mechanism of simvastatin against cognitive decline in AD. 27687042 2017
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		0.050 GeneticVariation phenotype BEFREE The haplotype effect was stronger than that of KL-VS. Two variants, rs2283368 and rs9526984, were the only variants significantly associated with cognitive decline over 7 years. 26405063 2016
CUI: C0234985
Disease: Mental deterioration
Mental deterioration 		0.050 Biomarker phenotype BEFREE Whether anti-aging factors such as klotho can counteract cognitive decline is unknown. 24813892 2014