|
Impaired cognition
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the upregulation of Klotho expression in the brain may promote the autophagic clearance of amyloid beta and protect against cognitive deficits in AD mice.
|
30851437 |
2019 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, Klotho G-395 A polymorphisms were associated with urolithiasis and cardiovascular disease but not with cognitive impairment.
|
30633899 |
2019 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the results do not support the hypothesis that KL-VS has a modifying effect on Aβ burden and APOE ε4-driven cognitive decline in preclinical AD.
|
30716541 |
2019 |
|
Impaired cognition
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The serum klotho level is a potential predictor of cerebrovascular disease in hemodialysis patients, but it is not an independent risk factor of cognitive impairment for hemodialysis patients with cerebrovascular disease.
|
30791885 |
2019 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most notably, Klotho deficiency is associated with a phenotype comprising organ manifestations accompanying aging including atherosclerosis and cognitive impairment.
|
31055648 |
2019 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Most notably, Klotho deficiency is associated with a phenotype comprising organ manifestations accompanying aging including atherosclerosis and cognitive impairment.
|
29274997 |
2018 |
|
Impaired cognition
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A reduced blood α-Klotho level was correlated with grading of cerebral DWMLs and was accompanied by cognitive decline as an independent risk factor.
|
29154273 |
2018 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study is to investigate the effects of LIG on cognitive deficits and metabolism of both APP and Klotho and its underlying mechanism in AD double-transgenic (APP/PS1) mice and cultured human cells.
|
29163135 |
2017 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the absence of the age-regulating klotho protein causes klotho-deficient mice to rapidly develop cognitive impairment and increasing klotho enhances hippocampal-dependent memory, the cellular effects of klotho that mediate hippocampal-dependent memory function are unknown.
|
28837861 |
2017 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Latency of klotho-/- mice in passive avoidance test was larger in linagliptin group than in control group (P < 0.05), indicating the amelioration of cognitive impairment by linagliptin.
|
29195509 |
2017 |
|
Impaired cognition
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our current study indicates that klotho upregulation may be a neuroprotective mechanism of simvastatin against cognitive decline in AD.
|
27687042 |
2017 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The haplotype effect was stronger than that of KL-VS. Two variants, rs2283368 and rs9526984, were the only variants significantly associated with cognitive decline over 7 years.
|
26405063 |
2016 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
This observation substantiates data from other laboratories that have reported that loss of Klotho accelerates the development of aging-like phenotypes, including cognitive deficits, whereas Klotho overexpression extends life span and enhances cognition in mice and humans.
|
27125744 |
2016 |
|
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
KLOTHO G-395A polymorphism associates with reduced cognitive impairment in a sample of Chinese nonagenarians and centenarians.
|
26732817 |
2016 |
|
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Augmenting klotho or its effects may enhance cognition and counteract cognitive deficits at different life stages.
|
24813892 |
2014 |