|
Vascular calcification
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Several pathogenic mechanisms such as inflammation-related endothelial dysfunction, mineral metabolism disorders, activation of the renin-angiotensin system, reduction of nitric oxide, lipid disorders, and the fibroblast growth factor 23-klotho axis are involved in the pathogenesis of atherosclerosis and arteriosclerosis, including VC.
|
31801144 |
2020 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Thus, the present study aimed to investigate the association of VC and myocardial remodeling and to analyze their relationship with VC promoters (fibroblast growth factor 23-FGF23, Klotho, intact parathormon-iPTH, vitamin D) in 56 prevalent HD patients (median values: age 54 yrs, HD vintage 82 months).
|
30867641 |
2019 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This review focuses on mechanisms activated during normal aging, for example, cellular senescence, autophagy, extracellular vesicles secretion, and oxidative stress, along with the convergence of premature aging models' pathophysiology, such as Hutchinson-Gilford Progeria (prelamin accumulation) and Klotho deficiency, to understand vascular calcification in aging.
|
31144990 |
2019 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Aortic vasorin expression was reduced in the hyperphosphatemic klotho-hypomorphic mouse model of CKD-related vascular calcification.
|
31505229 |
2019 |
|
Vascular calcification
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
α-Klotho is mainly expressed in the kidneys, and its soluble form can prevent vascular calcifications.
|
30943481 |
2019 |
|
Vascular calcification
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Finally, an in vivo study demonstrated that oral administration of rosiglitazone could increase Klotho expression and protect against high phosphate-induced vascular calcification in CKD mice.
|
29197521 |
2018 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Analysis of klotho-hypomorphic mice and mice with vitamin D<sub>3</sub> overload uncovered several pathophysiological mechanisms participating in the orchestration of vascular calcification and several therapeutic opportunities to delay or even halt vascular calcification.
|
29780355 |
2018 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
This review will discuss the current experimental and clinical evidence regarding FGF23 and Klotho, with a particular focus on their roles in LVH, atherosclerosis, and VC.
|
28294047 |
2018 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Further studies are warranted to elucidate potential roles of FGF23 and α-Klotho in VC and to determine where and how they are synthesized in normal and disease conditions.
|
27847254 |
2017 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Chronic Hyperphosphatemia and Vascular Calcification Are Reduced by Stable Delivery of Soluble Klotho.
|
27837149 |
2017 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Deficiency in α-Klotho is involved in the pathogenesis of vascular calcification.
|
26880455 |
2016 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Transcriptional suppression of vascular Klotho gene expression by IS and epigenetic modification of Klotho by IS may be an important pathological mechanism of vascular calcification in CKD.
|
27766038 |
2016 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Klotho-hypomorphic mice (kl/kl) suffer from severe vascular calcification and rapid aging.
|
26307633 |
2016 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Most importantly, prevention of αKlotho decline, upregulation of endogenous αKlotho production, or direct supplementation of soluble αKlotho are all associated with attenuation of renal fibrosis, retardation of CKD progression, improvement of mineral metabolism, amelioration of cardiac function and morphometry, and alleviation of vascular calcification in CKD.
|
27125746 |
2016 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
More importantly, rapamycin failed to reduce VC in the absence of Klotho by using either siRNA knockdown of Klotho or Klotho knockout mice.
|
26061549 |
2015 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
A paradigm of FGF23 excess and Klotho deficiency is proposed, in which FGF23 preferentially stimulates left ventricular hypertrophy, and loss of Klotho augments fibrosis, endothelial dysfunction, and vascular calcification.
|
25498378 |
2014 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Klotho ameliorates vascular calcification by enhancing phosphaturia, preserving glomerular filtration, and directly inhibiting phosphate uptake by vascular smooth muscle.
|
21115613 |
2011 |
|
Vascular calcification
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
In our adequately powered candidate gene study, we did not observe an association with the functional KL-VS variant of Klotho and presence of valvular or vascular calcification.
|
21565945 |
2011 |
|
Vascular calcification
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The klotho gene is involved in the development of a syndrome resembling human ageing, and klotho mutant mice show abnormal calcium/vitamin D metabolism, developing hyperphosphataemia and vascular calcification.
|
12771308 |
2003 |