NRXN3, neurexin 3, 9369

N. diseases: 64; N. variants: 29
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.150 GeneticVariation disease BEFREE This study aims to test whether 10 polymorphisms in obesity-related genes methionine sulfoxide reductase A (MSRA), transcription factor AP-2 beta (TFAP2B), melanocortin 4 receptor (MC4R), neurexin 3 (NRXN3), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A), transmembrane protein 18 (TMEM18), homolog of S. cerevisiae Sec16 (SEC16B), homeobox B5 (HOXB5) and olfactomedin 4 (OLFM4) are associated with the risk of obesity in Portuguese children. 24670271 2014
CUI: C0028754
Disease: Obesity
Obesity 		0.150 GeneticVariation disease GWASCAT Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.150 GeneticVariation disease BEFREE Recent researches have implicated that mutations in the neurexin-3 (NRXN3) gene on chromosome 14q24.3-q31.1 might play a role in addiction, autism, and obesity. 23306218 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.150 GeneticVariation disease GWASDB Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.150 Biomarker disease BEFREE The subject of our interest was genes: FTO, MC4R and NRXN3-associated with obesity. 21688152 2012
CUI: C0028754
Disease: Obesity
Obesity 		0.150 GeneticVariation disease GWASDB A genome-wide association study on obesity and obesity-related traits. 21552555 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.150 GeneticVariation disease BEFREE The minor G-allele of rs10146997 in NRXN3 associated with increased WC among women (β = 0.55cm (0.20;0.89), p(additive) = 1.7×10(-3), p(interaction) = 1.0×10(-3)), but showed no associations with obesity related metabolic traits. 21674055 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.150 GeneticVariation disease GWASCAT A genome-wide association study on obesity and obesity-related traits. 21552555 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.150 GeneticVariation disease BEFREE Our findings establish that common variants in NRXN3 are associated with WC, BMI, and obesity. 19557197 2009