Carcinogenesis
|
0.100 |
PosttranslationalModification
|
phenotype |
BEFREE |
These results demonstrated that <i>COX-2</i> promoter methylation was significantly higher in tumor tissues, and was an early event for GC, thus, <i>COX-2</i> gene methylation may be important in the initial development of gastric carcinogenesis.
|
30079321 |
2018 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The importance of cyclooxygenase-2 (<i>COX-2</i>) in carcinogenesis has been previously established and the use of <i>COX-2</i> inhibitors as celecoxib has been shown to exert antitumor effects.
|
28611669 |
2017 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Recent studies have shown that different adenomas are characterized by different pathways of carcinogenesis as well as diverse COX-2 expression in various polyps.
|
26469098 |
2015 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Inflammation has been linked to PC.Reports have cited an increased expression of proinflammatory mediators, such as NF-κB and COX, in PC but not in normal adjacent tissue, suggesting a possible role in carcinogenesis.
|
23360921 |
2013 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Experiments were designed to assess the chemopreventive effects of a novel dual 5-LOX/COX inhibitor, licofelone {[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid}, in APC(Min/+) mouse intestinal tumorigenesis.
|
21885812 |
2011 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Cyclooxygenase (COX) enzymes, COX1 and COX2, are key in converting arachidonic acid (AA) into prostaglandins that have been associated with colorectal carcinogenesis.
|
19205707 |
2009 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
GPx-mediated regulation of COX/LOX activities may be relevant to early stages of inflammation-mediated carcinogenesis.
|
19289149 |
2009 |
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The aim of this article is to present a review of COX genes, the prostaglandin-cyclooxygenase relationship, the role of COX-2 in carcinogenesis and the rationale for targeting COX-2 with NSAIDs for cancer chemoprevention.
|
12494894 |
2003 |
Carcinogenesis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Two Cox genes have been cloned, of which Cox-2 has been connected with gastric carcinogenesis.
|
14616542 |
2003 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Two Cox genes have been cloned, and expression of Cox-2 mRNA and protein has been shown to be elevated in several human malignancies and in animal models of carcinogenesis.
|
11448905 |
2001 |
Carcinogenesis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Cyclooxygenase-2 (COX-2) is an inducible form of COX and is overexpressed in diverse tumors, raising the possibility of a role for COX-2 in carcinogenesis.
|
11381123 |
2001 |