NRXN1, neurexin 1, 9378

N. diseases: 139; N. variants: 41
Disease: Abnormal behavior ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.030 GeneticVariation phenotype BEFREE The two deletions upstream of the NRXN1 gene were found to segregate with psychiatric disorders in the family and further similar deletions have been observed in patients diagnosed with autism spectrum disorder. 26563496 2015
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.030 GeneticVariation phenotype BEFREE The breakpoint at 2p was within the NRXN1 gene that has previously been associated with autism, intellectual disabilities, and psychiatric disorders. 21739571 2011
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.030 AlteredExpression phenotype BEFREE NRXN1 is highly expressed in brain and has been shown recently to be associated with ASD, schizophrenia, cognitive and behavioral abnormalities, and alcohol and nicotine dependence. 20162629 2010