CD28, CD28 molecule, 940

N. diseases: 364; N. variants: 11
Disease: IMMUNE SUPPRESSION ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1840264
Disease: IMMUNE SUPPRESSION
IMMUNE SUPPRESSION 		0.030 Biomarker phenotype BEFREE Our findings support the use of CD28 based CAR-Tregs for tissue specific immune suppression in the clinic. 30869654 2019
CUI: C1840264
Disease: IMMUNE SUPPRESSION
IMMUNE SUPPRESSION 		0.030 Biomarker phenotype BEFREE Studies with human T cells blocked for CD28 and with T cells from CD28 knockout mice demonstrated that CD80-Fc simultaneously inhibited PD-L1/PD-1-mediated immune suppression and delivered costimulatory signals to activated T cells, thereby amplifying T cell activation. 25792524 2015
CUI: C1840264
Disease: IMMUNE SUPPRESSION
IMMUNE SUPPRESSION 		0.030 Biomarker phenotype BEFREE The B7 costimulatory molecules govern many aspects of T cell immune responses by interacting with CD28 for costimulation, but also with CTLA-4 for immune suppression. 18832683 2008