CD80, CD80 molecule, 941

N. diseases: 233; N. variants: 5
Disease: Sepsis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis 		0.030 AlteredExpression disease BEFREE To elucidate the possible relationship between LPS-induced renal damage, proteinuria, and CD80 expression in Gram sepsis, a swine model of LPS-induced AKI was set up. 30672713 2019
CUI: C0243026
Disease: Sepsis
Sepsis 		0.030 Biomarker disease BEFREE Also, the overexpression of major histocompatibility complex class II (MHC II) and other costimulatory molecules (CD80 and CD86) in macrophages essentially indicates that SslE promotes macrophage activation and M1 polarization, which are crucial in framing the host's innate immune response to this protein, and hence, SslE could be a potent immunotherapeutic target against <i>E. coli</i> sepsis. 29891541 2018
CUI: C0243026
Disease: Sepsis
Sepsis 		0.030 AlteredExpression disease BEFREE However, these data also demonstrate differential regulation of CD80 and CD86 expression in sepsis, suggesting a divergent role for these receptors. 19672303 2009