NTN1, netrin 1, 9423

N. diseases: 209; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4748869
Disease: MIRROR MOVEMENTS 4
MIRROR MOVEMENTS 4 		0.400 GeneticVariation disease UNIPROT Mutations in the netrin-1 gene cause congenital mirror movements. 28945198 2017
CUI: C4748869
Disease: MIRROR MOVEMENTS 4
MIRROR MOVEMENTS 4 		0.400 CausalMutation disease CLINVAR
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.350 Biomarker disease BEFREE The endovascular perforation SAH model was constructed using male C57BL/6J mice, and recombinant NTN-1 was administrated intravenously. 30614619 2019
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.350 Biomarker disease BEFREE This study was designed to discern the utility of serum netrin-1 as a biomarker for assessing the severity and prognosis of patients with aneurysmal SAH. 31047878 2019
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.350 AlteredExpression disease BEFREE Our results showed that endogenous NTN-1 and its receptor UNC5B level were increased after SAH. 29162556 2018
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.350 Biomarker disease CTD_human Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats. 29162556 2018
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.350 AlteredExpression disease BEFREE The expression of endogenous NTN-1 and its receptor Deleted in Colorectal Cancer were increased after SAH. 28526701 2017
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.350 AlteredExpression disease BEFREE Our results revealed that endogenous NTN-1 level was increased after SAH. 28347836 2017
CUI: C0006114
Disease: Cerebral Edema
Cerebral Edema 		0.300 Therapeutic phenotype CTD_human Knockdown of endogenous NTN-1 increased expression of pro-inflammatory mediators and MPO, and aggravated neuroinflammation and brain edema. 29162556 2018
CUI: C0270192
Disease: Perinatal Subarachnoid Hemorrhage
Perinatal Subarachnoid Hemorrhage 		0.300 Biomarker phenotype CTD_human Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats. 29162556 2018
CUI: C0472383
Disease: Subarachnoid Hemorrhage, Spontaneous
Subarachnoid Hemorrhage, Spontaneous 		0.300 Biomarker phenotype CTD_human Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats. 29162556 2018
CUI: C0472387
Disease: Vasogenic Cerebral Edema
Vasogenic Cerebral Edema 		0.300 Therapeutic phenotype CTD_human Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats. 29162556 2018
CUI: C0472388
Disease: Cytotoxic Cerebral Edema
Cytotoxic Cerebral Edema 		0.300 Therapeutic phenotype CTD_human Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats. 29162556 2018
CUI: C0525041
Disease: Neurobehavioral Manifestations
Neurobehavioral Manifestations 		0.300 Therapeutic phenotype CTD_human Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats. 29162556 2018
CUI: C0750969
Disease: Vasogenic Brain Edema
Vasogenic Brain Edema 		0.300 Therapeutic phenotype CTD_human Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats. 29162556 2018
CUI: C0750970
Disease: Cytotoxic Brain Edema
Cytotoxic Brain Edema 		0.300 Therapeutic phenotype CTD_human Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats. 29162556 2018
CUI: C0751530
Disease: Subarachnoid Hemorrhage, Aneurysmal
Subarachnoid Hemorrhage, Aneurysmal 		0.300 Biomarker phenotype CTD_human Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats. 29162556 2018
CUI: C0795688
Disease: Subarachnoid Hemorrhage, Intracranial
Subarachnoid Hemorrhage, Intracranial 		0.300 Biomarker phenotype CTD_human Recombinant Netrin-1 binding UNC5B receptor attenuates neuroinflammation and brain injury via PPARγ/NFκB signaling pathway after subarachnoid hemorrhage in rats. 29162556 2018
CUI: C1527311
Disease: Brain Edema
Brain Edema 		0.300 Therapeutic phenotype CTD_human Knockdown of endogenous NTN-1 increased expression of pro-inflammatory mediators and MPO, and aggravated neuroinflammation and brain edema. 29162556 2018
CUI: C0008924
Disease: Cleft upper lip
Cleft upper lip 		0.110 Biomarker disease BEFREE NTN1 gene was risk to non-syndromic cleft lip only among Han Chinese population. 30506619 2019
CUI: C0008924
Disease: Cleft upper lip
Cleft upper lip 		0.110 GeneticVariation disease GWASCAT Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate. 28054174 2017
CUI: C0454455
Disease: Mirror movements disorder
Mirror movements disorder 		0.110 GeneticVariation disease BEFREE Mutations in the netrin-1 gene cause congenital mirror movements. 28945198 2017
CUI: C0008924
Disease: Cleft upper lip
Cleft upper lip 		0.110 GeneticVariation disease GWASCAT Genome-wide association study identifies a new susceptibility locus for cleft lip with or without a cleft palate. 25775280 2015
CUI: C0008924
Disease: Cleft upper lip
Cleft upper lip 		0.110 GeneticVariation disease GWASDB Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. 22863734 2012
CUI: C0008924
Disease: Cleft upper lip
Cleft upper lip 		0.110 GeneticVariation disease GWASDB A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. 20436469 2010