NTN1, netrin 1, 9423

N. diseases: 209; N. variants: 16
Disease: Diabetes Mellitus, Non-Insulin-Dependent ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 AlteredExpression disease BEFREE In vivo, aorta adventitial remodeling was accompanied with the down-regulation of netrin-1 in the perivascular sympathetic nerve in T2DM rats. 31846437 2020
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 Biomarker disease BEFREE More importantly, after further encoding a guide RNA targeting Ntn1 (sgNtn1) into the plasmid, the resultant CLAN<sub>pM330/sgNtn1</sub> successfully disrupted the Ntn1 gene in macrophages and their precursor monocytes in vivo, which reduced expression of netrin-1 (encoded by Ntn1) and subsequently improved type 2 diabetes (T2D) symptoms. 29314827 2018
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 AlteredExpression disease BEFREE Serum netrin-1 levels were independently associated with IFG or type 2 diabetes (standardized β = 0.405, <i>P</i> < 0.001) after adjusting for covariates and potential confounders. 30532735 2018