OPN4, opsin 4, 94233

N. diseases: 87; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 Biomarker disease BEFREE In this review, we briefly summarise the melanopsin system in the normal retina and discuss its role in connection to human aging (sleep/wake problems) and retinal pathology in Alzheimer and Parkinson diseases, diabetic retinopathy, mitochondrial optic neuropathies, glaucoma, retinitis pigmentosa, and in photophobia during migraine and in seasonal affective disorder (SAD). 31219170 2019
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 GeneticVariation disease BEFREE Two single-nucleotide polymorphisms (SNPs) in human melanopsin (hOPN4), Pro10Leu and Thr394Ile, have recently been associated with abnormal NIF responses to light, including seasonal affective disorder. 29718372 2018
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 Biomarker disease BEFREE <b>Conclusions:</b> This report provides initial evidence of normal melanopsin function and environmental light exposures in patients with pre-dominately mid and moderate non-seasonal depression in a subtropical location in the southern hemisphere. 30271376 2018
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 Biomarker disease PSYGENET Here we outline steps for new research to address the possible role of melanopsin in seasonal affective disorder including chromatic pupillometry designed to measure the sensitivity of melanopsin containing retinal ganglion cells. 23286902 2013
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 Biomarker disease BEFREE Here we outline steps for new research to address the possible role of melanopsin in seasonal affective disorder including chromatic pupillometry designed to measure the sensitivity of melanopsin containing retinal ganglion cells. 23286902 2013
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 Biomarker disease PSYGENET However, it is unclear if melanopsin increases risk of SAD by causing differences in sleep or circadian phase, or if those differences are symptoms of the mood disorder. 22881342 2012
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 GeneticVariation disease BEFREE However, it is unclear if melanopsin increases risk of SAD by causing differences in sleep or circadian phase, or if those differences are symptoms of the mood disorder. 22881342 2012
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 GeneticVariation disease BEFREE Other studies reported on mRGCs in glaucoma, on genetic variation of the melanopsin gene (OPN4) in seasonal affective disorder and on the role of mRGCs in migraineous photophobia. 20691201 2011
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 Biomarker disease PSYGENET Other studies reported on mRGCs in glaucoma, on genetic variation of the melanopsin gene (OPN4) in seasonal affective disorder and on the role of mRGCs in migraineous photophobia. 20691201 2011
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 GeneticVariation disease BEFREE These findings support the hypothesis that melanopsin variants may predispose some individuals to SAD. 18804284 2009
CUI: C0085159
Disease: Seasonal Affective Disorder
Seasonal Affective Disorder 		0.370 Biomarker disease PSYGENET These findings support the hypothesis that melanopsin variants may predispose some individuals to SAD. 18804284 2009
CUI: C1704436
Disease: Peripheral Arterial Diseases
Peripheral Arterial Diseases 		0.100 GeneticVariation group GWASCAT Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. 27082954 2016
CUI: C0026205
Disease: Miosis disorder
Miosis disorder 		0.090 Biomarker disease BEFREE The inner retinal melanopsin-expressing ipRGCs mediate the longer-term, sustained pupil constriction to set the light-adapted pupil diameter during extended light exposures. 31191431 2019
CUI: C0085648
Disease: Synovial Cyst
Synovial Cyst 		0.090 GeneticVariation disease BEFREE Contributions of the Melanopsin-Expressing Ganglion Cells, Cones, and Rods to the Pupillary Light Response in Obstructive Sleep Apnea. 31310657 2019
CUI: C0085648
Disease: Synovial Cyst
Synovial Cyst 		0.090 Biomarker disease BEFREE While rods, cones, and intrinsically photosensitive melanopsin-containing ganglion cells (ipRGCs) all drive light entrainment of the master circadian pacemaker of the suprachiasmatic nucleus, recent studies have proposed that entrainment of the mouse retinal clock is exclusively mediated by a UV-sensitive photopigment, neuropsin (OPN5). 30822304 2019
CUI: C1258666
Disease: Myxoid cyst
Myxoid cyst 		0.090 GeneticVariation disease BEFREE Contributions of the Melanopsin-Expressing Ganglion Cells, Cones, and Rods to the Pupillary Light Response in Obstructive Sleep Apnea. 31310657 2019
CUI: C1258666
Disease: Myxoid cyst
Myxoid cyst 		0.090 Biomarker disease BEFREE While rods, cones, and intrinsically photosensitive melanopsin-containing ganglion cells (ipRGCs) all drive light entrainment of the master circadian pacemaker of the suprachiasmatic nucleus, recent studies have proposed that entrainment of the mouse retinal clock is exclusively mediated by a UV-sensitive photopigment, neuropsin (OPN5). 30822304 2019
CUI: C0026205
Disease: Miosis disorder
Miosis disorder 		0.090 Biomarker disease BEFREE Melanopsin-mediated pupillary constriction resulted in a substantial reduction in the light sensitivity of the ChR2-mediated OMR. 29625451 2018
CUI: C0026205
Disease: Miosis disorder
Miosis disorder 		0.090 Biomarker disease BEFREE For example, light-evoked melanopsin activation in extra retinal tissue regulates pupil constriction in the iris and vasodilation in the vasculature of the heart and tail. 29905117 2018
CUI: C0026205
Disease: Miosis disorder
Miosis disorder 		0.090 Biomarker disease BEFREE Melanopsin- and L-cone-induced pupil constriction is inhibited by S- and M-cones in humans. 29311335 2018
CUI: C0026205
Disease: Miosis disorder
Miosis disorder 		0.090 Biomarker disease BEFREE Out of 84 pupil measurements (42 each in the depression and control groups), the melanopsin-mediated PIPR amplitude, transient pupil response, and pupil constriction amplitude were not significantly different between groups. 30271376 2018
CUI: C0085648
Disease: Synovial Cyst
Synovial Cyst 		0.090 AlteredExpression disease BEFREE While most research efforts in mammals have focused on mRGCs in retina, recent studies reveal that melanopsin is expressed in non-retinal tissues. 29905117 2018
CUI: C0085648
Disease: Synovial Cyst
Synovial Cyst 		0.090 Biomarker disease BEFREE To investigate how melanopsin-mediated intrinsically photosensitive retinal ganglion cell (ipRGC) signals are integrated binocularly using chromatic pupillometry. 30326065 2018
CUI: C0085648
Disease: Synovial Cyst
Synovial Cyst 		0.090 Biomarker disease BEFREE Melanopsin Retinal Ganglion Cells and Pupil: Clinical Implications for Neuro-Ophthalmology. 30581410 2018
CUI: C0085648
Disease: Synovial Cyst
Synovial Cyst 		0.090 Biomarker disease BEFREE Melanopsin-expressing retinal ganglion cells are relatively resistant to excitotoxicity induced by N-methyl-d-aspartate. 29102785 2018