|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The gross appearance of the capsules as well as the presence, extent and depth of tumor cells on the luminal side and number of sections involved by lymphoma were determined by review of routine stains and CD30 immunohistochemistry.
|
31383966 |
2020 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Some of the A20-mCD99L2- cells exhibited H/RS‑cell like morphology, a decreased proliferative ability, a prolonged G2 phase and increased CD30 and CD15 expression.
|
23338758 |
2013 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies of LyP and cutaneous ALCL tissues and cell lines suggest a dual role for CD30/CD30 ligand interactions in regression of LyP and progression to lymphoma.
|
17387297 |
2007 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aiming to functionally analyze the malignant T cells at a clonal level, we generated a total of 150 T-cell clones (TCC) from lesional skin and peripheral blood of three patients with mycosis fungoides and one patient with a CD30+ lymphoma.
|
11357228 |
2001 |
|
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A distinct pathologic entity characterized by expression of the anaplastic lymphoma kinase (ALK) protein (hence described as ALK lymphoma) has emerged within the heterogeneous group of CD30 anaplastic large-cell lymphomas.
|
19131793 |
2008 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ALCL was described initially as a subtype of T-cell/null-cell lymphoma characterized by unusual tumor cell morphology and the expression of CD30.
|
12202671 |
2002 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recurrent cutaneous anaplastic large cell (CD30+) lymphoma associated with Epstein-Barr virus. A case report with 9-year follow-up.
|
1323224 |
1992 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To our knowledge, primary cutaneous CD30+ natural killer type lymphoma has not been reported previously.
|
11048978 |
2000 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We discuss the diagnostic and clinical implications in the case of a 42-yr-old female with a peripheral CD30+ lymphoma that displayed both characteristic B- and T-cell surface antigens and clonal rearrangement of B- and T-cell antigen receptor gene loci.
|
17635241 |
2007 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Areas covered: The following article examines the current and emerging monoclonal antibody-based therapies for CTCL, with a particular focus on mycosis fungoides, primary cutaneous anaplastic large cell CD30+ lymphoma and Sezary syndrome.
|
28829215 |
2017 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To mobilize both adoptive and innate immune cells for an anti-tumor attack we fused the pro-inflammatory cytokines IL2 and IL12 to an anti-CD30 scFv antibody in a dual cytokine fusion protein to accumulate both cytokines at the malignant CD30(+) Hodgkin/Reed-Sternberg cells in the lymphoma lesion.
|
23028547 |
2012 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To definitively clarify whether the large atypical CD30(+) cells in LyP without associated lymphoma all belong to the same clone or represent individually rearranged T cells, we analyzed the T-cell receptor-gamma rearrangements of single CD30+ as well as of single CD30- cells isolated from 14 LyP lesions of 11 patients.
|
12091351 |
2002 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
While our understanding of the biology of CD30 in lymphoma continues to evolve, our need to detect and measure its expression at the protein level remains critically important for diagnosis and patient care.
|
31567279 |
2020 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Once a diagnosis of lymphoma is established, it is important to exclude systemic anaplastic lymphoma kinase-negative ALCL involving the breast, primary cutaneous ALCL, and other CD30(+) lymphoproliferative disorders.
|
24878027 |
2014 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The relatively benign clinical course of this lymphoma type has been explained with CD30-induced apoptosis, on the assumption that expression of CD30 defines the tumor clone; however, this hypothesis has not been tested on the molecular level to date.
|
12648233 |
2003 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A 47-year-old woman developed numerous violaceous nodules in the perineal and upper thigh area 3 years after multimodal treatment and complete remission of primary anaplastic large-cell CD30+ lymphoma.
|
20055841 |
2009 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD30 expression in extranodal natural killer/T-cell lymphoma, nasal type among 622 cases of mature T-cell and natural killer-cell lymphoma at a single institution in South China.
|
28486951 |
2017 |
|
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thirty-four cases were classified as anaplastic large cell lymphomas (ALCL), 2 cases as non-anaplastic large cell lymphomas (LCL), and 1 case as the small cell variant of CD30+ lymphoma.
|
7856744 |
1995 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proliferation of the CD30+ lymphoma cell line Karpas-299 was strongly inhibited by CD30-specific huTR protein (IC50=3.3 nM).
|
18230757 |
2008 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Upon cocultivation with autologous CD30(+)lymphoma cells, grafted T cells increase IFN-gamma secretion and lyse specifically lymphoma cells with high efficiency, even at an effector to target cell ratio of as low as 1:20.
|
11423937 |
2001 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our objective is to understand the mechanism of progression of lymphomatoid papulosis (LyP) to CD30+ systemic lymphoma.
|
11594583 |
2001 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD30 is promising target as it is universally expressed in virtually all classical Hodgkin lymphomas, anaplastic large cell lymphomas, and in a proportion of other lymphoma types, including cutaneous T cell lymphomas and diffuse large B cell lymphomas.
|
30841880 |
2019 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Galectin-1 (Gal-1) has been associated with adverse prognosis in several cancers including lymphoma entities with CD30 expression.
|
31834627 |
2020 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Epstein-Barr virus has been implicated in the etiology of endemic Burkitt's lymphoma, post-transplant lymphoma, large-cell anaplastic CD30 (Ki-1)-positive lymphoma, and in many T-cell lymphomas.
|
8539233 |
1995 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Anaplastic large-cell lymphoma (ALCL) is a lymphoma that expresses CD30.
|
21366363 |
2011 |