|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD30 shedding from Karpas 299 lymphoma cells is mediated by TNF-alpha-converting enzyme.
|
11120787 |
2000 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD30+ Reed-Sternberg and diffuse large B-cell lymphoma cells contained Epstein-Barr virus EBER sequences that were not observed at the level of mucosa-associated lymphoid tissue-type lymphoma.
|
12459631 |
2002 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD30 expression in extranodal natural killer/T-cell lymphoma, nasal type among 622 cases of mature T-cell and natural killer-cell lymphoma at a single institution in South China.
|
28486951 |
2017 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD30 is promising target as it is universally expressed in virtually all classical Hodgkin lymphomas, anaplastic large cell lymphomas, and in a proportion of other lymphoma types, including cutaneous T cell lymphomas and diffuse large B cell lymphomas.
|
30841880 |
2019 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A 47-year-old woman developed numerous violaceous nodules in the perineal and upper thigh area 3 years after multimodal treatment and complete remission of primary anaplastic large-cell CD30+ lymphoma.
|
20055841 |
2009 |
|
Adult Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A distinct pathologic entity characterized by expression of the anaplastic lymphoma kinase (ALK) protein (hence described as ALK lymphoma) has emerged within the heterogeneous group of CD30 anaplastic large-cell lymphomas.
|
19131793 |
2008 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A loss of response to transforming growth factor-beta, which normally dampens cellular proliferation, may differentiate CD30+ lymphoma from lymphomatoid papulosis.
|
8806956 |
1996 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A patient with fibrosing alveolitis developed a diffuse large B-cell (DLBC) lymphoma that expressed CD20 and CD30.
|
15257558 |
2004 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aiming to functionally analyze the malignant T cells at a clonal level, we generated a total of 150 T-cell clones (TCC) from lesional skin and peripheral blood of three patients with mycosis fungoides and one patient with a CD30+ lymphoma.
|
11357228 |
2001 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ALCL was described initially as a subtype of T-cell/null-cell lymphoma characterized by unusual tumor cell morphology and the expression of CD30.
|
12202671 |
2002 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although initially found in primary nodal ALCL, recent studies suggest that NPM-ALK expression may occur in lymphoma at extranodal sites, including the skin; it remains controversial, however, whether CD30+ primary cutaneous lymphoma and its benign counterpart, lymphomatoid papulosis (LyP), express NPM-ALK in some cases.
|
9684923 |
1998 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Anaplastic large-cell lymphoma (ALCL) is a lymphoma that expresses CD30.
|
21366363 |
2011 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Areas covered: The following article examines the current and emerging monoclonal antibody-based therapies for CTCL, with a particular focus on mycosis fungoides, primary cutaneous anaplastic large cell CD30+ lymphoma and Sezary syndrome.
|
28829215 |
2017 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD56/neural cell adhesion molecule expression in primary extranodal Ki-1/CD30+ lymphoma. Report of a pediatric case with simultaneous cutaneous and bone localizations.
|
9261474 |
1997 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD8<sup>+</sup> LyP with lack of expression of CD30 may have distinct histopathologic features that resemble mycosis fungoides and LyP type B. Clinically, they are indistinguishable from their CD30<sup>+</sup> counterparts, signifying the importance of clinical correlation to avoid the erroneous diagnosis of lymphoma.
|
30520526 |
2019 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expert commentary: Recognition of CD30 expression in lymphoma has led to the development of important therapeutic options.
|
27927047 |
2017 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Galectin-1 (Gal-1) has been associated with adverse prognosis in several cancers including lymphoma entities with CD30 expression.
|
31834627 |
2020 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that chicken Marek's disease (MD) lymphoma cells are also CD30(hi) and are a unique natural model for CD30(hi) lymphoma.
|
15356338 |
2004 |
|
Adult Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunotherapy of CD30-expressing lymphoma using a highly stable ssDNA aptamer.
|
23968853 |
2013 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the context of the MD lymphoma microenvironment (and potentially in other CD30(hi) lymphomas as well), our results show that the neoplastic transformation is a continuum and the non-neoplastic cells are actually pre-neoplastic precursor cells and not merely immune bystanders.
|
22979947 |
2012 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
No mutation was detected in any of the three CD30-positive Alc lymphoma analyzed, whereas an aberrant SSCP pattern was found in all the four SNCC samples tested.
|
8617454 |
1996 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Once a diagnosis of lymphoma is established, it is important to exclude systemic anaplastic lymphoma kinase-negative ALCL involving the breast, primary cutaneous ALCL, and other CD30(+) lymphoproliferative disorders.
|
24878027 |
2014 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our objective is to understand the mechanism of progression of lymphomatoid papulosis (LyP) to CD30+ systemic lymphoma.
|
11594583 |
2001 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proliferation of the CD30+ lymphoma cell line Karpas-299 was strongly inhibited by CD30-specific huTR protein (IC50=3.3 nM).
|
18230757 |
2008 |
|
Adult Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, the tumor necrosis factor receptor superfamily cluster of differentiation 30 (CD30) has been thought to be implicated in malignant cells in organs affected by Hodgikin lymphoma or in a prognostic marker of diffuse large B cell lymphoma.
|
31335688 |
2019 |