|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Natural killer group 2D (NKG2D) is a natural killer (NK) cell-activating receptor that recognizes different stress-induced ligands that are overexpressed in a variety of childhood and adult tumors.
|
31649672 |
2019 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The Natural Cytotoxicity Receptors (NCRs), NKp46, NKp44, and NKp30, were some of the first human activating Natural Killer (NK) cell receptors involved in the non-MHC-restricted recognition of tumor cells to be cloned over 20 years ago.
|
31134055 |
2019 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Using transgenic mice, NKp44 binding of tumor-expressed PDGF-DD was able to limit tumor growth, and expression of natural cytotoxicity receptor-associated gene signatures (of which NKp44 is a member) was correlated to clinical outcomes.
|
30086799 |
2018 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
A distinctive transcriptional signature of PDGF-DD-induced cytokines and the downregulation of tumor cell-cycle genes correlated with NCR2 expression and greater survival in glioblastoma.
|
29275861 |
2018 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
We therefore identified the NKp44 binding site to PCNA and further developed an NKp44-peptide-based agent that can inhibit tumor growth through interfering with the function of intracellular PCNA in the tumor cell.
|
29875773 |
2018 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The natural cytotoxicity receptors (NCRs; NKp30, NKp44, and NKp46) were first defined as activating receptors on human NK cells that are important in recognition of and response to tumors.
|
29264698 |
2018 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Our results show that expression in primary lymphocytes of an NCR2-derived CAR, termed s4428z, confers T-cells with the ability to specifically recognize heterogeneous tumors and to mediate tumor cytotoxicity in a mouse model.
|
29085357 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
However, if grouped according to the NKp44 splice variant profile, NKp44-1 expression was significantly associated with poor survival of AML patients.
|
27102296 |
2016 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Analysis of in vitro IL-2-expanded NK cells from patients with myelocytic/monocytic acute myeloid leukemia (AML-NK cells) has revealed poor cytolytic functions because of deficient expression of pivotal activation molecules-the natural cytotoxicity receptors (NCRs) NKp30, NKp44, and NKp46.
|
16940427 |
2007 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, flow cytometry analysis of 20 samples of patients with acute myeloid leukemia (AML) (FAB M0-M5) revealed the expression of NKG2D (40%) and other natural cytotoxicity receptors (40% for NKp30, 74% for NKp44, 39% for NKp46) by a pool >15% of leukemic cells.
|
16239914 |
2005 |
|
HIV Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Thus, our study showed that NKp44 have a protective effect on astrocytes from NK cell mediated killing during HIV infection and impact astrocyte role in HAND.
|
29447242 |
2018 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or viral infection.
|
28767057 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or viral infection.
|
28767057 |
2017 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Therefore, we studied the profiles of NKp44 and NKp30 splice variants in these states by comparing (i) decidua from pregnancy disorder and healthy gestation and (ii) matched normal and cancer tissue.
|
27765926 |
2016 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Therefore, we studied the profiles of NKp44 and NKp30 splice variants in these states by comparing (i) decidua from pregnancy disorder and healthy gestation and (ii) matched normal and cancer tissue.
|
27765926 |
2016 |
|
Influenza
|
0.020 |
Biomarker
|
disease |
BEFREE |
We previously reported that NKp44 recognizes the hemagglutinin of influenza virus (IV).
|
17536787 |
2007 |
|
HIV Infections
|
0.020 |
AlteredExpression
|
group |
BEFREE |
A substantial percentage of natural killer (NK) cells from patients with HIV infection are activated and express the natural cytotoxicity receptor (NCR) NKp44.
|
16046540 |
2005 |
|
Influenza
|
0.020 |
Biomarker
|
disease |
BEFREE |
Recently, we have identified a novel functional interaction between the lysis receptors NKp46 and NKp44 and the hemagglutinin of influenza and hemagglutinin-neuroaminidase of Sendai viruses.
|
14504081 |
2004 |
|
Crohn Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Importantly, CD62L expression was absent on human ILCs expressing NKp44 in tonsils and PB of Crohn disease patients, and relatively fewer CD62L<sup>+</sup> ILCP were present in PB of Crohn disease patients.
|
30504420 |
2019 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We reported however that circulating and tumor-infiltrating γδT cells from melanoma patients displayed an altered expression of NCR, KIR, and immune checkpoints, and identified NKp44, PD1, 41BB/41BBL, TIM3, and LAG3 as crucial checkpoints allowing immune escape and tumor progression.
|
31413911 |
2019 |
|
Severe Aplastic Anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Activating receptors NKp46 and NKp44 on CD56<sup>bright</sup> NK cells were upregulated while inhibiting receptor NKG2A was downregulated in SAA.
|
30779419 |
2019 |
|
Juvenile arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Group 1 ILCs (ILC1s), NKp44- group 3 ILCs (natural cytotoxicity receptor-negative [NCR-] ILC3s), and NKp44+ ILC3s (NCR+ ILC3s) were enriched in JIA SFMCs compared to PBMCs, which corresponded to an increase in transcripts for TBX21, IFNG, and IL17A.
|
30350355 |
2019 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A distinctive transcriptional signature of PDGF-DD-induced cytokines and the downregulation of tumor cell-cycle genes correlated with NCR2 expression and greater survival in glioblastoma.
|
29275861 |
2018 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Regarding the association with clinic pathologic features, increased expression of NKp44 was associated with lower values of LDH and earlier stages of DLBCL (p<0.05).
|
29247708 |
2018 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A distinctive transcriptional signature of PDGF-DD-induced cytokines and the downregulation of tumor cell-cycle genes correlated with NCR2 expression and greater survival in glioblastoma.
|
29275861 |
2018 |