Colorectal Carcinoma
|
0.310 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
Hepatitis C
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The variation of the NKp46 proportion in individuals could be attributed to the diversity of HCV resistance observed in these individuals, which possibly reflects the clinical outcome of infection in patients.
|
26714120 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46.
|
14504081 |
2004 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NKp46/Ncr1 also recognizes unknown self and tumor ligands.
|
29026144 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As a result, NKGD2-deficient (Klrk1<sup>-/-</sup>) mice controlled tumors and cytomegalovirus infection better than wild-type controls through the NCR1-induced production of the cytokine IFN-γ.
|
30224819 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cases did not show differences in NKp46 demethylation based on tumor site or stage.
|
23014525 |
2012 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Ly5.1<sup>C14R</sup> NK cells expressed similar levels of <i>Ncr1</i> mRNA as C57BL/6, but showed impaired surface NKp46 and reduced ability to control melanoma tumors <i>in vivo</i>.
|
30288342 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Despite a large body of evidence highlighting its importance in the clearance of both solid and liquid tumors, the membrane-bound tumor ligand for NKp46 and its mouse orthologue Ncr1 is still unknown.
|
31606778 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Hpsefl/fl NKp46-iCre mice were also more susceptible to tumor growth than were their littermate controls when challenged with the established mouse lymphoma cell line RMA-S-RAE-1β, which overexpresses the NK cell group 2D (NKG2D) ligand RAE-1β, or when inoculated with metastatic melanoma, prostate carcinoma, or mammary carcinoma cell lines.
|
28581441 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The natural cytotoxicity receptors (NCRs; NKp30, NKp44, and NKp46) were first defined as activating receptors on human NK cells that are important in recognition of and response to tumors.
|
29264698 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Using several mouse tumor models, we demonstrate the importance of NK cells in protection from reovirus infection and in reovirus killing of tumors <i>in vivo</i> Collectively, we identify a new ligand for the NKp46 receptor and provide evidence for the importance of NKp46 in the control of reovirus infections and in reovirus-based cancer therapy.
|
28724773 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We observe the downregulation of several activation receptors including CD16, CD62L, C-X-C chemokine receptor (CXCR)-4, natural killer group 2 member D (NKG2D), DNAX accessory molecule (DNAM)-1, and NKp46 following tumor-priming.
|
31242243 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, we demonstrated that blocking NKp46 receptor <i>in vitro</i> was able to restore spontaneous tumor specific T cell responses in NSCLC patients.
|
30713781 |
2019 |
Influenza
|
0.050 |
Biomarker
|
disease |
BEFREE |
The only definitive ligand of NCR1 is influenza haemagglutinin, though there are believed to be others.
|
22212381 |
2012 |
Influenza
|
0.050 |
Biomarker
|
disease |
BEFREE |
There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1(gfp/gfp) mice, and influenza virus infection was lethal in both 129/Sv and C57BL/6 Ncr1(gfp/gfp) mice.
|
16565719 |
2006 |
Influenza
|
0.050 |
Biomarker
|
disease |
BEFREE |
Recently, we have identified a novel functional interaction between the lysis receptors NKp46 and NKp44 and the hemagglutinin of influenza and hemagglutinin-neuroaminidase of Sendai viruses.
|
14504081 |
2004 |
Influenza
|
0.050 |
Biomarker
|
disease |
BEFREE |
The influenza virus hemagglutinin (HA) was the first ligand identified for Ncr1/NKp46 followed by other viral, bacterial and even fungal ligands.
|
29026144 |
2017 |
Influenza
|
0.050 |
Biomarker
|
disease |
BEFREE |
In contrast, loss of NCR1 increased susceptibility to influenza virus, a result that is consistent with the role of NCR1 in the recognition of influenza Ag, hemagglutinin.
|
29440507 |
2018 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Using several mouse tumor models, we demonstrate the importance of NK cells in protection from reovirus infection and in reovirus killing of tumors <i>in vivo</i> Collectively, we identify a new ligand for the NKp46 receptor and provide evidence for the importance of NKp46 in the control of reovirus infections and in reovirus-based cancer therapy.
|
28724773 |
2017 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Most importantly, we showed that a toxin-conjugated 02 inhibits the growth of NKp46-positive cells; thus, exemplifying the potential of 02 in becoming an immunotherapeutic drug to treat NKp46-dependent diseases, such as, type I diabetes and NK and T cell related malignancies.
|
30536875 |
2019 |
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Here, we provide a simple and rapid protocol for the generation of transgenic mice expressing Cre recombinase in a cell type-specific manner-in our example we chose cells expressing Ncr1, which encodes for the surface protein NKp46-and the use of those mice to ablate NKp46+ cells in order to study their role in a model of cancer immunosurveillance against experimental pulmonary metastases.
|
30465202 |
2019 |
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Here, we provide a simple and rapid protocol for the generation of transgenic mice expressing Cre recombinase in a cell type-specific manner-in our example we chose cells expressing Ncr1, which encodes for the surface protein NKp46-and the use of those mice to ablate NKp46+ cells in order to study their role in a model of cancer immunosurveillance against experimental pulmonary metastases.
|
30465202 |
2019 |
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Using several mouse tumor models, we demonstrate the importance of NK cells in protection from reovirus infection and in reovirus killing of tumors <i>in vivo</i> Collectively, we identify a new ligand for the NKp46 receptor and provide evidence for the importance of NKp46 in the control of reovirus infections and in reovirus-based cancer therapy.
|
28724773 |
2017 |