Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.310 GeneticVariation disease UNIPROT
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.020 AlteredExpression disease LHGDN NK cell lytic activity against M. tuberculosis-infected monocytes and NKp46 mRNA expression were reduced in tuberculosis patients with ineffective immunity to M. tuberculosis compared with findings in healthy donors. 11907104 2002
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.020 AlteredExpression disease BEFREE NK cell lytic activity against M. tuberculosis-infected monocytes and NKp46 mRNA expression were reduced in tuberculosis patients with ineffective immunity to M. tuberculosis compared with findings in healthy donors. 11907104 2002
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46. 14504081 2004
CUI: C0021400
Disease: Influenza
Influenza 		0.050 Biomarker disease BEFREE Recently, we have identified a novel functional interaction between the lysis receptors NKp46 and NKp44 and the hemagglutinin of influenza and hemagglutinin-neuroaminidase of Sendai viruses. 14504081 2004
CUI: C0023473
Disease: Myeloid Leukemia, Chronic
Myeloid Leukemia, Chronic 		0.010 Biomarker disease BEFREE NKp46 and NKp30 are the major receptors involved in the NK-mediated killing of K562, a human chronic myelogenous leukaemia cell line. 15654827 2005
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.030 AlteredExpression disease BEFREE Interestingly, flow cytometry analysis of 20 samples of patients with acute myeloid leukemia (AML) (FAB M0-M5) revealed the expression of NKG2D (40%) and other natural cytotoxicity receptors (40% for NKp30, 74% for NKp44, 39% for NKp46) by a pool >15% of leukemic cells. 16239914 2005
CUI: C0522631
Disease: Acute myeloid leukemia, minimal differentiation
Acute myeloid leukemia, minimal differentiation 		0.010 AlteredExpression disease BEFREE Interestingly, flow cytometry analysis of 20 samples of patients with acute myeloid leukemia (AML) (FAB M0-M5) revealed the expression of NKG2D (40%) and other natural cytotoxicity receptors (40% for NKp30, 74% for NKp44, 39% for NKp46) by a pool >15% of leukemic cells. 16239914 2005
CUI: C0021400
Disease: Influenza
Influenza 		0.050 Biomarker disease BEFREE There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1(gfp/gfp) mice, and influenza virus infection was lethal in both 129/Sv and C57BL/6 Ncr1(gfp/gfp) mice. 16565719 2006
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.030 Biomarker group BEFREE There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1(gfp/gfp) mice, and influenza virus infection was lethal in both 129/Sv and C57BL/6 Ncr1(gfp/gfp) mice. 16565719 2006
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.030 Biomarker disease BEFREE Our longitudinal study of AML patients showed that the NCR(dull) phenotype was acquired during leukemia development because we observed its complete (for NKp46) or partial (for NKp30) reversibility in patients achieving complete remission (CR). 16940427 2007
CUI: C0023418
Disease: leukemia
leukemia 		0.020 Biomarker disease BEFREE Our longitudinal study of AML patients showed that the NCR(dull) phenotype was acquired during leukemia development because we observed its complete (for NKp46) or partial (for NKp30) reversibility in patients achieving complete remission (CR). 16940427 2007
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.020 Biomarker disease BEFREE Our longitudinal study of AML patients showed that the NCR(dull) phenotype was acquired during leukemia development because we observed its complete (for NKp46) or partial (for NKp30) reversibility in patients achieving complete remission (CR). 16940427 2007
CUI: C0278144
Disease: Dull pain
Dull pain 		0.010 Biomarker phenotype BEFREE Our longitudinal study of AML patients showed that the NCR(dull) phenotype was acquired during leukemia development because we observed its complete (for NKp46) or partial (for NKp30) reversibility in patients achieving complete remission (CR). 16940427 2007
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.020 Biomarker disease LHGDN These results indicate that vimentin is involved in binding of NKp46 to M. tuberculosis H37Ra-infected mononuclear phagocytes. 17056548 2006
CUI: C0000786
Disease: Spontaneous abortion
Spontaneous abortion 		0.010 AlteredExpression phenotype LHGDN The patients with SA expressed higher proportion of NKp44 on CD56(bright)CD16(-)dNK and higher proportions of NKp46 and NKp44 on CD56(dim)CD16(+)dNK with statistical significance. 18023431 2008
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.020 Biomarker disease BEFREE Our findings demonstrate that NKp46 is essential for the development of type 1 diabetes and highlight potential new therapeutic modalities for this disease. 20023661 2010
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome 		0.010 Biomarker disease BEFREE Expression and function of the natural cytotoxicity receptor NKp46 on circulating malignant CD4+ T lymphocytes of Sézary syndrome patients. 21191411 2011
CUI: C0023418
Disease: leukemia
leukemia 		0.020 Biomarker disease BEFREE Thus, IL-15 signaling and NKp46 may be useful targets in the treatment of patients with T-LGL or NKT leukemia. 21364281 2011
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.020 Biomarker disease BEFREE Thus, IL-15 signaling and NKp46 may be useful targets in the treatment of patients with T-LGL or NKT leukemia. 21364281 2011
CUI: C1955861
Disease: T-Cell Large Granular Lymphocyte Leukemia
T-Cell Large Granular Lymphocyte Leukemia 		0.010 AlteredExpression disease BEFREE Virtually 100% of T-LGL leukemias in IL-15 transgenic mice expressed NKp46, as did a majority of human T-LGL leukemias. 21364281 2011
CUI: C0021400
Disease: Influenza
Influenza 		0.050 Biomarker disease BEFREE The only definitive ligand of NCR1 is influenza haemagglutinin, though there are believed to be others. 22212381 2012
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.020 AlteredExpression disease BEFREE Rather, the major part of NCR1 expression was localised to astrocytes, and was considerably more pronounced in MS patients than controls. 22212381 2012
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.010 AlteredExpression disease BEFREE In order to further validate de novo expression of NCR1 in astrocytes, we used an in vitro staining of the human astrocytoma U251 cell line grown to model whether cell stress could be associated with expression of NCR1. 22212381 2012
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.010 AlteredExpression disease BEFREE In order to further validate de novo expression of NCR1 in astrocytes, we used an in vitro staining of the human astrocytoma U251 cell line grown to model whether cell stress could be associated with expression of NCR1. 22212381 2012