ITM2B, integral membrane protein 2B, 9445

N. diseases: 77; N. variants: 3
Disease: Fibrillation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0232197
Disease: Fibrillation
Fibrillation 		0.030 Biomarker disease BEFREE Finally, Bri2 BRICHOS inhibits several steps in the Aβ42 fibrillation pathway and prevents aggregation of heat-denatured proteins, indicating that it is a more versatile chaperone than proSP-C BRICHOS. 27514716 2016
CUI: C0232197
Disease: Fibrillation
Fibrillation 		0.030 Biomarker disease BEFREE BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells. 25336154 2015
CUI: C0232197
Disease: Fibrillation
Fibrillation 		0.030 Biomarker disease BEFREE Interestingly, BRI2 is a potential regulator of AβPP processing, and it can inhibit the production and fibrillation of Aβ. 24473189 2014