LY86, lymphocyte antigen 86, 9450

N. diseases: 11; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0006663
Disease: Calcinosis
Calcinosis 		0.300 Biomarker phenotype CTD_human Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure. 21335463 2011
CUI: C0018824
Disease: Heart valve disease
Heart valve disease 		0.300 Biomarker group CTD_human Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure. 21335463 2011
CUI: C0263628
Disease: Tumoral calcinosis
Tumoral calcinosis 		0.300 Biomarker disease CTD_human Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure. 21335463 2011
CUI: C0521174
Disease: Microcalcification
Microcalcification 		0.300 Biomarker phenotype CTD_human Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure. 21335463 2011
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism 		0.120 Biomarker phenotype BEFREE LY86 encodes for MD-1 which down-regulates the pro-inflammatory response to lipopolysaccharide; LY86 variation was previously associated with VTE in white women; LOC100130298 is a non-coding RNA gene with unknown regulatory activity in gene expression and epigenetics. 28203683 2017
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism 		0.120 GeneticVariation phenotype GWASCAT Identification of unique venous thromboembolism-susceptibility variants in African-Americans. 28203683 2017
CUI: C1861172
Disease: Venous Thromboembolism
Venous Thromboembolism 		0.120 GeneticVariation phenotype BEFREE In stratified analyses, SNPs in the following genes were significantly associated with VTE: F5 and ABO among both genders and LY86 among women; F2, ABO and KLKB1 among FV Leiden non-carriers; F5, F11, KLKB1 and GFRA1 in those with ABO non-O blood type; and ABO, F5, F11, KLKB1, SCUBE1 and SELP among prothrombin G20210A non-carriers. 21463476 2011
CUI: C0009319
Disease: Colitis
Colitis 		0.010 AlteredExpression disease BEFREE We discovered that MD-1 protein expression was remarkably decreased in both patients with ulcerative colitis and mice with DSS-induced colitis. 31104313 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.010 AlteredExpression disease BEFREE We discovered that MD-1 protein expression was remarkably decreased in both patients with ulcerative colitis and mice with DSS-induced colitis. 31104313 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.010 GeneticVariation disease BEFREE One CpG site in the lymphocyte antigen 86 (LY86) gene, which showed higher methylation in the obese in both the initial (p = .009) and second genome-wide DNA methylation panel (p = .008), was further validated in both replication panels (meta p = .00016). 24735745 2014
CUI: C0004096
Disease: Asthma
Asthma 		0.010 GeneticVariation disease BEFREE Genotyping 34 SNPs in the MD-1 gene region was performed in a case-control study involving 281 children with asthma and 237 controls. 19255686 2008
CUI: C0270850
Disease: Idiopathic generalized epilepsy
Idiopathic generalized epilepsy 		0.010 GeneticVariation disease BEFREE Single nucleotide polymorphisms and haplotype of MD-1 gene associated with high serum IgE phenotype with mite-sensitive allergy in Taiwanese children. 18001295 2007