leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The cells of CD34+ primary leukemia and CD38- KG-1, and TF-1 were separated by flow cytometry.
|
31307525 |
2019 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD34-enriched primary AML cells with aberrant leukemia-associated phenotypes (LAPs) were cultured on stromal cells.
|
29431553 |
2018 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The level of OCT1 mRNA expression was lowest for CD34+ leukemia.
|
28025785 |
2017 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, CD34+ clusters showed more important prognostic impact on survival and progression to leukaemia.
|
28669578 |
2017 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed that CD7+/CD34+ or CD7+/CD34- T-ALL cells that promote leukemia within a short-time period are genetically similar, as well as xenograft-derived leukemia resulting from both cell fractions.
|
27191650 |
2016 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Xenograft transplantation studies have demonstrated a rare population of leukemia-initiating cells called leukemic stem cells (LSCs) capable of propagating leukemia that are enriched in the CD34+/CD38- fraction.
|
27465508 |
2016 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By screening different blood cancers, we have observed that this activity is not always restricted to CD34+ leukemic cells, and can be overexpressed in CD34 negative leukemia.
|
27732563 |
2016 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together with the knowledge that WA had no apparent suppressive effect on the growth of human normal bone marrow CD34-positive cells in the short-term culture, this drug may have a potential for a novel therapeutic approach to the treatment of leukemia or MDS.
|
27311589 |
2016 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We explored whether KRAS activation cooperates with MA4 to initiate leukemia in cord blood-derived CD34(+) hematopoietic stem/progenitor cells (HSPC).
|
26837759 |
2016 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
When ALL cells were sorted and assessed in functional assays, all 4 subpopulations (CD34+/CD99+, CD34+/CD99-, CD34-/CD99+ and CD34-/CD99-) could proliferate in vitro and establish leukemia in NSG mice.
|
27764235 |
2016 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study revealed that ADRM1 was overexpressed in AL, especially in CD34+ leukemia stem and progenitor cells.
|
25896055 |
2015 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ectopic expression of SOX7 in K562 and THP-1 cells, as well as primary CD33(+)CD34(+) AML cells, abrogated leukemia engraftment in xenogeneic transplantation.
|
25940713 |
2015 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In MLL-AF4 patients, CD34(+)CD38(+)CD19(+) and CD34(-)CD19(+) cells initiated leukemia, and in MLL-AF9 patients, CD34(-)CD19(+) cells were LICs.
|
25538041 |
2015 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A Leukemia-Associated CD34/CD123/CD25/CD99+ Immunophenotype Identifies FLT3-Mutated Clones in Acute Myeloid Leukemia.
|
25957287 |
2015 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The antibody decreased proliferation of the primary T-ALL cells and depleted leukemia initiating CD34/CD44 high population.
|
26046801 |
2015 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Flk1(+)CD31(-)CD34(-) MSCs that express BCR/ABL leukemia oncogene are hemangioblasts and they have a critical role in the progression of CML through PI3K/Akt/NF-κB signaling pathway.
|
25837664 |
2015 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD200 was more frequent in secondary compared to de novo leukemia (p = 0.0006), in CD34 positive cases (p = 0.00001), in Bcl2 overexpressing cases (p = 0.01), in those wild-type Flt3 (p = 0.004) and with favorable or unfavorable compared to intermediate karyotype (p = 0.0003).
|
26338961 |
2015 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consequently, the presence of leukemic cell subsets with variable levels of CD71 and CD34 may be useful for understanding the dynamic processes involved in the clonal development seen in leukemias.
|
23962073 |
2014 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, Np9 protein level was correlated with the number of leukemia stem/progenitor cells but not detected in normal CD34(+) hematopoietic stem cells.
|
23307033 |
2013 |
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Flk1(+)CD31(-)CD34(-) MSCs that express BCR/ABL leukemia oncogene are CSCs of CML and they play a critical role in the progression of CML through PI3K/Akt/NF-κB/MMP-9/s-ICAM-1/s-KitL signaling pathway beyond HSCs.
|
23180012 |
2013 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In acute myeloid leukemia (AML), the leukemia initiating cells (LICs) or leukemia stem cells (LSCs) is found within the CD34+CD38- cell compartment.
|
24517186 |
2013 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Combination treatment also statistically significantly enhanced apoptosis of CD34(+) leukemic stem/progenitor cells and eliminated their long-term leukemia-initiating activity in NSG mice.
|
23446755 |
2013 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have also shown that CD34(+) /CD38(-) AML cells, one of compartments enriched for leukemia stem cells in most leukemia subgroups, were relatively resistant to cytarabine-mediated growth inhibition when compared to their CD34(+) /CD38(+) counterparts.
|
23686525 |
2013 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Relapse of acute myeloid leukemia (AML) is thought to reflect the failure of current therapies to adequately target leukemia stem cells (LSCs), the rare, resistant cells presumed responsible for maintenance of the leukemia and typically enriched in the CD34(+)CD38(-) cell population.
|
22262762 |
2012 |
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, peptide inhibition of BCL6 in human CML cells compromises colony formation and leukemia initiation in transplant recipients and selectively eradicates CD34(+) CD38(-) LICs in patient-derived CML samples.
|
21911423 |
2011 |