Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In acute lymphoblastic leukemia (ALL), LSCs frequently express CD34 and often lack CD38.
|
29772458 |
2018 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A seven-color panel including CD34 and TdT could be applied in >97% patients with T cell lymphoblastic leukemia for minimal residual disease detection independent of the initial phenotype.
|
30059823 |
2018 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The most frequent diagnosis was myelodysplastic syndrome (MDS) in 14 patients (35%), followed by acute lymphoid leukemia (ALL) in 12 (30%).The mean of CD34+ was 2.09 × 106/kg.
|
28691152 |
2017 |
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
<i>Materials and methods</i> We compared DNA methylation of 1,505 selected promoter CpGs in chronic myelogenous leukemia (CML), acute lymphoblastic leukemia (ALL) with and without the Philadelphia chromosome t(9:22), CD34+ hematopoietic stem cells transfected with <i>BCR-ABL</i>, and other tumors without <i>BCR-ABL</i> (acute promyelocytic leukemia (APL) and gastrointestinal stromal tumors (GIST).
|
28730166 |
2017 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia.
|
25538041 |
2015 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the viability of healthy CD34+ hematopoietic progenitors was significantly reduced when co-cultured with ALL-MSCs.
|
24400095 |
2014 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD34 positivity was higher in BAL (87%) than in ALL (60%, P = 0.04) and AML patients (63%, P = 0.05).
|
22898323 |
2013 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The clinical and biological characteristics of ALL patients between the MyAg⁺ and MyAg⁻ groups showed that a higher percentage of patients with high WBC count (>50×10⁹/L) and higher CD34 positivity were found to be correlated with MyAg⁺ ALL.
|
21792039 |
2011 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used chromatin-immunoprecipitation on microarray to analyze histone 3 lysine 9 trimethylation (H3K9me3) patterns in primary AML (n = 108), acute lymphoid leukemia (n = 28), CD34(+) cells (n = 21) and white blood cells (n = 15) specimens.
|
20498303 |
2010 |
Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Distinct expression patterns of CD123 and CD34 on normal bone marrow B-cell precursors ("hematogones") and B lymphoblastic leukemia blasts.
|
19762535 |
2009 |
Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this retrospective study, we investigated the prognostic significance of the expression of the early T-cell differentiation marker CD34 and the expression of MDR genes in relation to outcome in a cohort of 72 newly diagnosed pediatric T-ALL patients.
|
18683236 |
2008 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data indicate that FTY720 induces apoptosis and impairs clonogenicity of imatinib/dasatinib-sensitive and -resistant p210/p190(BCR/ABL) myeloid and lymphoid cell lines and CML-BC(CD34+) and Ph1 ALL(CD34+/CD19+) progenitors but not of normal CD34+ and CD34+/CD19+ bone marrow cells.
|
17717597 |
2007 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
High BAALC expression correlated with a higher frequency of early T-ALL (P < .0001), CD34 positivity (P < .0001), coexpression of myeloid markers (P = .0001), and high ERG expression (P = .03).
|
17646667 |
2007 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A 35-year-old man was diagnosed as ALL because of the infiltration of CD10(+)CD19(+)CD33(+)CD34(+) lymphoblasts in the bone marrow and the expression of p190-type BCR/ABL fusion transcript.
|
16979235 |
2007 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Functional studies supported the microarray findings threefold: (1) higher expression of the glucose transport protein glucose transporter 1 in ALL compared to CD34+ specimens, (2) the excessive production of lactate in ALL cell lines and (3) sensitivity of ALL cell lines to the glycolysis inhibitor 2-deoxy-D-glucose.
|
17041637 |
2006 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Candidate leukaemic cell populations were defined by the antigen profiles CD34+CD38- in AML and CD34+CD19-CD117+ in ALL.
|
16643437 |
2006 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specifically, c-MYB (P </= 0.04) was significantly increased in ALL in the total fraction, whilst HOXA9 (P </= 0.19) and cystatin c (P </= 0.01) were increased in AML in the CD34(+) and CD34(-) fractions, respectively. c-MYB, hSNF2, RBAP48, HKRT-1, LYN, CD33, Adipsin and HOXA9 were increased in AML compared with remission AML, indicating an ability to determine disease activity.
|
16029452 |
2005 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8(+)CD34(+) T cells from patients with T-cell-lineage acute lymphocytic leukemia.
|
15580304 |
2005 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CLL-1 showed variable expression (10-60%) in CD34(+) cells in chronic myelogenous leukemia and myelodysplastic syndrome but was absent in 12 of 13 cases of acute lymphoblastic leukemia.
|
15548716 |
2004 |
Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In whole ALL, CD13/CD33 was associated closely with the presence of stem-cell antigen CD34, and in T-lineage ALL, CD13/CD33 had a significant correlation with additional stem-cell features, such as HLA-DR, multidrug resistance 1 (MDR1) and c-kit gene expression.
|
11531016 |
2001 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD34(+) leukemic cells from 2 B-ALL patients with the Philadelphia chromosome were similarly cultured, but in the presence of CD40-ligand and IL-4.
|
10477734 |
1999 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, GATA-2 mRNA and c-kit antigen could not be detected in CD34-positive cells from ALL patients.
|
9114595 |
1997 |
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cytogenetically aberrant cells are present in the CD34+CD33-38-19- marrow compartment in children with acute lymphoblastic leukemia.
|
9305606 |
1997 |
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Due to a different distribution of prognostic factors investigated, DFS and OS were both significantly better in CD34+ than in CD34- childhood ALL, whereas no statistical difference was found in adults.
|
9107079 |
1997 |
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
As concerns immunophenotypic findings, blast cells from two of three AML patients expressed CD7 and CD34, while those from the T-ALL case displayed CD33 and CD34 along with CD7.
|
8946942 |
1996 |