|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High-grade GISTs were more likely to have lower CD34 expression and a higher Ki-67 proliferation index compared to the matched low-grade tumors.
|
31570771 |
2020 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
The IHC characteristic of GIST in descending order showed positivity for vimentin (88.9%), CD117 (83.3%), CD34 (77.8%), Ki67 (63.9%), SMA (38.9%), desmin (27.8%), and S100 (19.4%).
|
30723856 |
2019 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
There were no differences in CD34+ staining features between the main GISTs and the laterally spreading lesions.
|
29658593 |
2018 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
Histology confirmed a gastrointestinal stromal tumour (figure 2, which was smooth muscle actin positive (figure 3), S-100 positive, vimentin positive, but c-KIT negative (figure 4), CD34 positive and desmin negative.
|
29592983 |
2018 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The cross validation SVM classifiers achieved with combination of stdDeviation, anatomic location and CD34_stain level demonstrated medium to good prediction efficiency (AUC = 0.864-0.904) regarding the GIST genotypes.
|
30292279 |
2018 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
Gastrointestinal stromal tumor (GIST) is believed to originate from intestinal cells of Cajal or their stem cell precursors, and expresses stemness-related markers, such as CD117, CD34, DOG1 and nestin.
|
29486292 |
2018 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
The biopsy specimen from the duodenum was GIST with positive immunostaining of KIT and CD34 microscopically.
|
28835241 |
2017 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
<i>Materials and methods</i> We compared DNA methylation of 1,505 selected promoter CpGs in chronic myelogenous leukemia (CML), acute lymphoblastic leukemia (ALL) with and without the Philadelphia chromosome t(9:22), CD34+ hematopoietic stem cells transfected with <i>BCR-ABL</i>, and other tumors without <i>BCR-ABL</i> (acute promyelocytic leukemia (APL) and gastrointestinal stromal tumors (GIST).
|
28730166 |
2017 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
After imatinib treatment, in both patients, the resected tumors were composed of heterogeneous spindle cells negative to KIT, DOG1, and CD34 IHC staining, which was unusual for GIST.
|
29245294 |
2017 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
This study aimed at understanding the regulation of CD34 in GISTs and clarification of its site-dependent expression.
|
28744850 |
2017 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
Immuhistochemical analysis of CD34 and CD117 was performed on GIST biopsy samples from both siblings, while c-kit mutational analysis was done by PCR and direct sequencing on DNA from peripheral blood leukocytes of all family members and from paraffin-embedded gastric biopsy specimens of affected siblings.
|
28074523 |
2017 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
DOG1 antibodies are a sensitive and specific marker against GIST positive for CD117 and CD34 and negative for CD117 and CD34.
|
26678977 |
2015 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
Additional transcripts relevant to GIST biology were also evaluated, including members of the IGF-signaling pathway (IGF1, IGF2, and insulin receptor [INSR]), neural markers (CDH2[CDH: Cadherin], neurofilament, light polypeptide, LHX2 [LHX: LIM homeobox], and KIRREL3 [KIRREL: kin of IRRE like]), KIT, PDGFRA, CD34, and HIF1A.
|
24133624 |
2013 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
Most gastric gastrointestinal stromal tumors (GISTs) display spindle cell morphology and coexpress CD117 (KIT), DOG-1, and CD34.
|
23218903 |
2013 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Gastrointestinal stromal tumors showing cystic degeneration after imatinib treatment lack CD34 expression.
|
22952296 |
2012 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
Fine-needle aspiration biopsy revealed spindle cells with moderate pleomorphism and immunohistochemically reactive to CD117 and CD34 suggestive of GIST, but the clinical picture was unusual for GIST.
|
21666577 |
2011 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A total of 152 primary and metastatic lesions in 33 cases of GISTs were examined for histologic and immunohistochemical expression of KIT and CD34.
|
20180814 |
2010 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Compared with the overall mutation rate (8.7%) of exon 9, GISTs with CD34+SMA+ had > or = 20% probability of harboring an exon 9 mutation, and all GISTs in the small intestine had a probability of 19%.
|
20123583 |
2010 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The diagnosis of GISTs relies on histological arguments--proliferation of spindle-shaped cells in 70% of cases, of epithelioid cells in 20%, histological variants are rare--, and on immunohistochemical arguments--expression of CD117 in 95%, usually associated with CD34 expression in 70% of cases.
|
19690756 |
2009 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
KIT-negative GISTs also showed lower expression rates of CD34, Bcl-2, and PKC than KIT-positive GISTs; mutational analysis revealed that 30% of KIT-negative GISTs harboured a PDGFRA exon 18 mutation.
|
18381383 |
2008 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
This antibody yielded positive staining in 370 of 425 (87%) scorable GIST, whereas CD117 was positive in 317 of 428 (74%) GIST and CD34 in 254 of 430 (59%) GIST.
|
18223323 |
2008 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
Biomarker
|
group |
BEFREE |
The findings confirmed the usefulness of CD117 and CD34 in diagnosing GIST and the prognostic role of MIB-1, but do not support a correlation between aneuploidy in flow cytometry and poor outcome.
|
17914946 |
2007 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Histological examination showed that these tumors were GISTs expressing CD34 and CD117.
|
16586562 |
2006 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Positivity of CD117 and CD34 is the most valuable factor in diagnosing GIST.
|
16830365 |
2006 |
|
Gastrointestinal Stromal Tumors
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Most GISTs (95%) express Kit (CD117), CD34 (70%), and heavy caldesmon (80%), whereas 25% are positive for smooth muscle actin and less than 5% for desmin.
|
17090188 |
2006 |