|
Giant Cell Fibroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunostaining for CD34 showed diffuse and strong cytoplasmic expression in neoplastic cells, whereas that for alpha smooth muscle actin, factor XIIIa, S-100 and melan-A were negative.The tumor was diagnosed as DFSP.
|
30952756 |
2019 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In children, cutaneous and superficial soft-tissue neoplasms with CD34-positive spindle cells are associated with benign to intermediate malignancy potential and include lipofibromatosis, plaque-like CD34-positive dermal fibroma, fibroblastic connective tissue nevus, and congenital dermatofibrosarcoma protuberans.
|
30187166 |
2019 |
|
Giant Cell Fibroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All cases of classic DFSP had diffuse expression of CD34 and low-level p53 immunoreactivity.
|
29140881 |
2018 |
|
Giant Cell Fibroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Two metastatic alveolar rhabdomyosarcomas were myf4 positive, a metastasis of a gynecologic leiomyosarcoma was positive for actin and estrogen receptor (ER) and a recurrent dermatofibrosarcoma protuberans expressed CD34.
|
29318761 |
2018 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because CD34 non-neoplastic mesenchymal cells were distributed in a location similar to that of DFSP, we suggest that DFSP might have originated from CD34 mesenchymal cells in the dermis.
|
28362700 |
2017 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemically, all DFSPs with sclerosing (predominant or mixed) pattern were positive for CD34, and 5/7 were at least focally positive for EMA.
|
28134725 |
2017 |
|
Giant Cell Fibroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Atypical fibrohistiocytic lesions (AFL) have features intermediate to DF and DFSP (trunk location, storiform pattern, infiltration of the subcutaneous tissue, and focal expression of both CD34 and Factor XIIIa).
|
28609344 |
2017 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Nestin is the best immunohistochemical marker for SAF with higher sensitivity than CD34, although nestin is also positive in dermatofibrosarcoma protuberans and therefore is not helpful in differential diagnosis between SAF and dermatofibrosarcoma protuberans.
|
28045748 |
2017 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Excision revealed a dermal and subcutaneous storiform spindle cell proliferation with fat entrapment and positive staining for CD34, consistent with DFSP.
|
26488716 |
2016 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Eligibility criteria included: biopsy or surgical resection; suspicion of: dermatofibrosarcoma protuberans (cohort 1), dedifferentiated liposarcoma (cohort 2), Ewing's sarcoma family of tumours (cohort 3), synovial sarcoma (cohort 4), alveolar rhabdomyosarcoma (cohort 5), and myxoid or round cell liposarcoma (cohort 6); review by one sarcoma-expert pathologist; availability of frozen material (except for cohort 1 of patients with dermatofibrosarcoma protuberans because anti-CD34 immunohistochemistry is performed on paraffin-embedded tissue); and patient information.
|
26970672 |
2016 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients who present with metastatic DFSP-FS show less typical histologic findings and loss of CD34 staining, leaving PDGFB rearrangement as the preferred adjunctive method for diagnosis from small biopsies and for prediction of the value of imatinib therapy.
|
23347652 |
2013 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Histologically, the primary and recurrent tumors comprised a high-grade spindle cell sarcoma, with a small component of storiform, low-grade, CD34-positive spindle cells, classic for an ordinary DFSP.
|
23108023 |
2012 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Differentiating dermatofibrosarcoma protuberans (DFSP) from other dermatofibromas using CD34 immunohistochemistry alone is difficult; therefore, fluorescence in situ hybridisation (FISH) analysis is often employed to identify typical COL1A1-PDGFB fusion or gene rearrangement.
|
22523339 |
2012 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
DFSP-FS was associated with tumor history longer than 5 years (P = .009), tumor size greater than 4 cm (P = .001), more stages of modified Mohs micrographic surgery (P = .005), expansive subcutaneous infiltration (P = .005), muscular invasion (P = .0001), absence of CD34 staining (P = .018), p53 positivity (P = .006), and increased proliferative activity (P = .004) compared with DFSP.
|
21570152 |
2011 |
|
Giant Cell Fibroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition to areas of conventional DFSP that strongly expressed CD34, 2 cases showed pleomorphic areas mimicking undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma: 1 case had a patternless area and 1 case had combined round/spindled cells with myxoid areas.
|
21478726 |
2011 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, all CD34 negative DFSP (n = 5) were positive for COL1A1/PDGFB translocation by both techniques.
|
21484928 |
2011 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plaque-like CD34-positive dermal fibroma ("medallion-like dermal dendrocyte hamartoma"): clinicopathologic, immunohistochemical, and molecular analysis of 5 cases emphasizing its distinction from superficial, plaque-like dermatofibrosarcoma protuberans.
|
20061935 |
2010 |
|
Giant Cell Fibroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The CD34 expression plays a key role in the differential diagnosis of some tumors, such as dermatofibrosarcoma protuberans, epithelioid sarcoma or pleomorphic hyalinizing angiectatic tumor of soft parts, with important therapeutic consequences.
|
19125742 |
2009 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study illustrates the difficulties and pitfalls of the recognition of congenital DFSP and emphasizes the value of immunohistochemical study with anti-CD34 and complementary molecular analysis for all cutaneous spindle cell tumors and plaques in neonates and infants.
|
17310000 |
2007 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical results showed that tumour cells in ordinary DFSP areas were diffusely positive for CD34, whereas in the FS and myxoid areas, few tumour cells were positive for this antigen.
|
16126884 |
2005 |
|
Giant Cell Fibroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Dermatofibrosarcoma protuberans (DP) is a rare, slow-growing, infiltrating dermal neoplasm of intermediate malignancy, made up of spindle-shaped tumor cells often positive for CD34.
|
12661001 |
2003 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
All tumors were diffusely positive for vimentin and CD34 but negative for smooth muscle actin, desmin, epithelial membrane antigen, and cytokeratins; one pure adult-type DFSP was also S-100 protein positive; <1% of nuclei were Ki67 (Mib-1) positive.
|
12502925 |
2003 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In all cases, both the giant cell fibroblastoma areas and dermatofibrosarcoma protuberans areas stained positively with CD34.
|
9700370 |
1998 |
|
Giant Cell Fibroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, CD34 antigen was expressed only in DFSP.
|
9550312 |
1998 |
|
Giant Cell Fibroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This benign tumor must be clearly distinguished from dermatofibrosarcoma protuberans, which also is composed of bundles of CD34-reactive spindle-shaped cells in most cases but has locally aggressive behavior.
|
8698923 |
1996 |