Lupus Erythematosus, Systemic
|
0.390 |
Biomarker
|
disease |
BEFREE |
HBV: hepatitis B virus; HCC hepatocellular carcinoma; TNFSF10: tumor necrosis factor superfamily member 10; ATG5: autophagy-related protein 5; DNA: deoxyribonucleic acid; LDR-PCR: ligase detection reactions-polymerase chain reaction; PCR: polymerase chain reaction; SLE: systemic lupus erythematosus; BD: Behçet's disease; IL-10: interlukin-10; LPS: lipopolysaccharide; PBMC: peripheral blood mononuclear cells; CWP: coal workers' pneumoconiosis; TNF-α: tumor necrosis factor-α.
|
30907204 |
2019 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to verify if ATG5 polymorphisms are involved in the susceptibility to disease and its clinical phenotypes in an Italian cohort of SLE patients.
|
29759048 |
2018 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.
|
27193031 |
2017 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
Lupus Erythematosus, Systemic
|
0.390 |
Biomarker
|
disease |
BEFREE |
With several single nucleotide polymorphisms (SNPs) in autophagy-related gene5 (ATG5) being linked to SLE susceptibility, more and more lines of evidence from animal model, cell biology, immunology, and genetics studies show that autophagy contributes to the occurrence, development, and severity of SLE.
|
27673477 |
2016 |
Lupus Erythematosus, Systemic
|
0.390 |
Biomarker
|
disease |
BEFREE |
Autophagy-related gene 5 (ATG5), ATG7, B-lymphoid tyrosine kinase (BLK) and B-cell scaffold protein with ankyrin repeats 1 (BANK1) are involved in B-cell signaling; several genome-wide association studies detected these genes as candidates involved in systemic lupus erythematosus (SLE).
|
26420661 |
2016 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Although these rare variants were observed to be located in the flanking regions of exons instead of missense mutations, patients carrying them tended to have severe clinical phenotype, and in silicon analysis suggested their regulatory effects.Increased frequencies of rare variants of ATG5 were identified in patients with LN and SLE compared with healthy controls, highlighting a likely important role of rare ATG5 variants in Chinese SLE patients.
|
26039132 |
2015 |
Lupus Erythematosus, Systemic
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Correlations between the trans-eSNPs and ATG5 expression and different expression levels of ATG5 in SLE patients and controls were validated, and their regulatory effects were annotated.
|
26509176 |
2015 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
Lupus Erythematosus, Systemic
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
First, we detected the expression of autophagy-related genes (Atg5, Atg12 and Beclin 1) in the macrophages derived from activated lymphocytes-derived DNA (ALD-DNA) induced murine lupus as well as in the PBMC from SLE patients.
|
25151985 |
2014 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the Atg5 rs573775 T* allele seems to influence SLE susceptibility, cytokine production and disease features depending on other factors such as functional IL-10 genotype.
|
24205307 |
2013 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population.
|
21622776 |
2011 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.
|
19838195 |
2009 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
|
18204446 |
2008 |
Lupus Erythematosus, Systemic
|
0.390 |
Biomarker
|
disease |
MGD |
|
|
|