Metabolic Syndrome X
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Metabolic syndrome is associated with the accumulation of CER in VAT, possibly related to increased FAT/CD36 protein expression.
|
30724038 |
2019 |
Metabolic Syndrome X
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this study, we tested our hypothesis that the periodontal expression of fatty acid receptors GPR40 and CD36 is increased in patients with both MetS and periodontitis.
|
30597558 |
2019 |
Metabolic Syndrome X
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The FA receptor CD36 has been linked to risk of metabolic syndrome.
|
29546316 |
2018 |
Metabolic Syndrome X
|
0.300 |
Biomarker
|
disease |
BEFREE |
In the past decade, microvesicles (MVs) and CD36 have increasingly been considered as possible biomarkers for obesity, the metabolic syndrome (MetSy), type 2 diabetes mellitus (T2DM).
|
30386406 |
2018 |
Metabolic Syndrome X
|
0.300 |
Biomarker
|
disease |
BEFREE |
Cluster of differentiation 36 (CD36), also named fatty acid translocase, is known to facilitate long-chain fatty acid uptake and contribute to the development of MS. We recently found that CD36 overexpression enhanced HBV replication.
|
28697919 |
2017 |
Metabolic Syndrome X
|
0.300 |
Biomarker
|
disease |
BEFREE |
<i>Conclusions.</i> Metabolic syndrome components and hepatic fat accumulation correlated with microvesicle phenotypes, supporting the involvement of especially CD36 on monocytes in metabolic syndrome pathogenesis.
|
28168203 |
2017 |
Metabolic Syndrome X
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
CD36 expression is upregulated in mice with periodontitis and MetS and involved in gene expression in macrophages stimulated by palmitate and LPS.
|
27753178 |
2017 |
Metabolic Syndrome X
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Effect of chronic sildenafil treatment on IS and FMD was tested in AA women with metabolic syndrome and with/without the CD36 variant, using a randomized, placebo-controlled trial (protocol 2).
|
27144937 |
2016 |
Metabolic Syndrome X
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Remarkably, rs11760281 in GNAT3 and rs1194197 near CD36 exhibited the strongest associations with MS (P = 0.0003, relative risk (RR) = 1.6 and P = 0.004, RR = 1.7, respectively) and several other related traits.
|
22456541 |
2012 |
Metabolic Syndrome X
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD36 is recognized as a lipid and fatty acid receptor and plays an important role in the metabolic syndrome and associated cardiac events.
|
22662181 |
2012 |
Metabolic Syndrome X
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Overall, the haplotype tagged SNPs of CD36 gene were not related to the risk of metabolic syndrome.
|
23249574 |
2012 |
Metabolic Syndrome X
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of the CD36 gene have been associated with metabolic syndrome (MetS).
|
22047506 |
2012 |
Metabolic Syndrome X
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our findings show that CD36 rs1761667 SNP is positively associated with increased risk of MetS and its components with genotype AG heterozygotes showing highest frequency among MetS patients.
|
22588808 |
2012 |
Metabolic Syndrome X
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this review we will describe the functions of CD36 in tissues and address the role of sCD36 in the context of the metabolic syndrome.
|
21250778 |
2011 |
Metabolic Syndrome X
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In humans, CD36 variants have been identified to influence free FA and high-density lipoprotein (HDL) levels and to associate with the risk of the metabolic syndrome, coronary artery disease and stroke.
|
20935172 |
2011 |
Metabolic Syndrome X
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
SNPs of CD36 were associated with metabolic syndrome in Puerto Ricans.
|
20223461 |
2010 |
Metabolic Syndrome X
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In addition, variants in the CD36 gene were shown recently to influence susceptibility for the metabolic syndrome, which greatly increases the risk of diabetes and heart disease.
|
19185504 |
2009 |
Metabolic Syndrome X
|
0.300 |
Biomarker
|
disease |
BEFREE |
We evaluated 36 tag SNPs across CD36 in the HyperGen population sample of 2020 African-Americans for impact on the MetS and its quantitative traits.
|
18305138 |
2008 |
Metabolic Syndrome X
|
0.300 |
Biomarker
|
disease |
BEFREE |
Such studies have also indicated that naturally occurring variation in genes, such as Cd36, that regulate fatty acid metabolism and ectopic accumulation of fat and fat metabolites can influence both biochemical and hemodynamic features of the metabolic syndrome and mediate the antidiabetic effects of drugs that activate the peroxisome proliferator-activated receptor-gamma.
|
17339535 |
2007 |
Metabolic Syndrome X
|
0.300 |
Biomarker
|
disease |
BEFREE |
The membrane-bound fatty acid transporter CD36/FAT may play a role in disturbed fatty acid handling as observed in the metabolic syndrome and Type 2 diabetes mellitus (T2DM).
|
16911630 |
2006 |
Metabolic Syndrome X
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, we have revealed that defective Cd36 is probably a candidate gene for disorded fatty-acid metabolism, glucose intolerance and insulin resistance in NIH-derived SHR, but other genes might play a role in pathogenesis of metabolic syndrome in Prague hereditary hypertriglyceridemic rats.
|
15209533 |
2004 |
Metabolic Syndrome X
|
0.300 |
Biomarker
|
disease |
BEFREE |
Genetics of Cd36 and the hypertension metabolic syndrome.
|
11891508 |
2002 |
Metabolic Syndrome X
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Association of the Pro90Ser CD36 mutation with elevated free fatty acid concentrations but not with insulin resistance syndrome in Japanese.
|
11718687 |
2001 |
Metabolic Syndrome X
|
0.300 |
Biomarker
|
disease |
RGD |
Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats.
|
9916795 |
1999 |