Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
The cluster of differentiation 81 (CD81) and scavenger receptor class B member 1 (SCARB1) plays an important role in the entry of hepatitis C virus (HCV).
|
29715527 |
2018 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
Bioreactor derived HCV showed high genetic stability, as well as buoyant density, sensitivity to neutralizing antibodies AR3A and AR4A, and dependency on HCV co-receptors CD81 and SR-BI comparable to that of HCV produced in monolayer cell cultures.
|
30504788 |
2018 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
The cell surface receptor SR-BI (scavenger receptor class B member 1), is essential for hepatitis C virus (HCV) entry into hepatocytes.
|
28363797 |
2017 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
SDC-1, SDC-2, TIM-1, and SR-BI were found to modestly promote HCV cell-to-cell spread.
|
28404852 |
2017 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interestingly, we found that this crosstalk modulates E1E2 binding to HCV entry receptors SR-BI and CD81.
|
24038151 |
2014 |
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These mutations modulated HCV dependence on the viral receptor SRB1, and/or they also modulated virion sensitivity to neutralizing antibodies.
|
24990994 |
2014 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
HCV particles entering target cells lost oxLDL sensitivity with time kinetics parallel to anti-SR-BI (scavenger receptor class B type I), but significantly earlier than anti-CD81, suggesting that oxLDL acts by perturbing interaction between HCV and SR-BI.
|
23212706 |
2013 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using phage display libraries, we have generated a large set of novel human mAbs against SR-BI and evaluated their effectiveness in preventing HCV infection and direct cell-to-cell spread in vitro and in vivo using uPA-SCID mice with a humanized liver.
|
22414763 |
2012 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
CD81 and scavenger receptor class B member I interact with HCV-encoded glycoproteins, suggesting an initial role in mediating virus attachment.
|
20375010 |
2010 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
LHGDN |
Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs.
|
19148942 |
2009 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hepatocytes in liver tissue coexpress CD81, SR-BI, and CLDN1, consistent with their ability to support HCV entry.
|
18085708 |
2008 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
LHGDN |
Scavenger receptor class B is required for hepatitis C virus uptake and cross-presentation by human dendritic cells.
|
18216094 |
2008 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
CTD_human |
Lipoprotein lipase mediates hepatitis C virus (HCV) cell entry and inhibits HCV infection.
|
17517063 |
2007 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
The human scavenger class B type 1 receptor (SR-B1/Cla1) was identified as a putative receptor for hepatitis C virus (HCV) because it binds to soluble recombinant HCV envelope glycoprotein E2 (sE2).
|
17507483 |
2007 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
LHGDN |
The human scavenger class B type 1 receptor (SR-B1/Cla1) was identified as a putative receptor for hepatitis C virus (HCV) because it binds to soluble recombinant HCV envelope glycoprotein E2 (sE2).
|
17507483 |
2007 |
Hepatitis C
|
0.400 |
Biomarker
|
disease |
LHGDN |
Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor.
|
12913001 |
2003 |