|
Malignant neoplasm of breast
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Disrupting NBCn1 expression delays ErbB2-induced breast cancer development, inhibits cancer cell proliferation, and decelerates tumor growth.
|
29907770 |
2018 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
BC patients (n = 1687) randomly sampled in an adjuvant, randomized phase III trial (SUCCESS A study) were genotyped for nine BC risk SNPs: rs17468277 <i>(CASP8)</i> , rs2981582 <i>(FGFR2)</i> , rs13281615(8q24), rs3817198 <i>(LSP1)</i> , rs889312 <i>(MAP3K1)</i> , rs3803662 <i>(TOX3)</i> , rs13387042(2q35), rs4973768 <i>(SLC4A7)</i> , rs6504950 <i>(COX11)</i> .
|
28757652 |
2017 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to estimate the heritability (h<sup>2</sup>) of breast cancer susceptibility through the analysis of 6 single nucleotide polymorphisms (SNPs), nuclear mitotic apparatus protein 1, cyclin D1, cytochrome C oxidase copper chaperone, fibroblast growth factor receptor 2, TOX high mobility group box family member 3 and solute carrier family 4 member 7.
|
28943953 |
2017 |
|
Malignant neoplasm of breast
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Collectively, this is the first work to demonstrate 3'UTR-mediated NBCn1 regulation, shows that p95HER2 regulates NBCn1 expression at multiple levels, and substantiates the central position of p95HER2-NBCn1 signaling in breast cancer.
|
27609814 |
2016 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Five of the 17 SNPs were significantly associated (P ≤ 0.05) with overall breast cancer in the same direction as previously reported: rs13387042 (2q35/TNP1), rs4973768 (3p24/SLC4A7), rs2046210 (6q25/ESR1), rs1219648 (10q26/FGFR2), and rs4784227 (16q12/TOX3).
|
24510657 |
2015 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Protein expression of the Na(+),HCO3 (-)-cotransporter NBCn1 (SLC4A7), which has been linked to breast cancer susceptibility in multiple genome-wide association studies, was twofold higher in human breast carcinomas compared to matched normal breast tissue.
|
24788003 |
2015 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We confirmed associations between rs13387042 (2q35), rs4973768 (SLC4A7), rs10941679 (5p12), rs2981582 (FGFR2), rs3817198 (LSP1), rs3803662 (TOX3), and rs6504950 (STXBP4) with breast cancer.
|
23893088 |
2013 |
|
Malignant neoplasm of breast
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
To determine whether NBCn1, by transporting HCO(3)(-) into cells, may dispose of acid produced during high metabolic activity, we studied the expression of NBCn1 and the functional impact of Na(+),HCO(3)(-)-cotransport in human breast cancer.
|
22907202 |
2013 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
|
23535729 |
2013 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Confirmed BC risk SNPs rs17468277 (CASP8), rs1982073 (TGFB1), rs2981582 (FGFR2), rs13281615 (8q24), rs3817198 (LSP1), rs889312 (MAP3K1), rs3803662 (TOX3), rs13387042 (2q35), rs4973768 (SLC4A7), rs6504950 (COX11) and rs10941679 (5p12) were genotyped for 25 853 BC patients with the available follow-up; 62 other SNPs, which have been suggested as BC risk SNPs by a GWAS or as candidate SNPs from individual studies, were genotyped for replication purposes in subsets of these patients.
|
22532573 |
2012 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In summary, our results showed that the SLC4A7 variant, rs4973768, is associated with risk of BC although the underlying biologic mechanism warrants further studies.
|
23117855 |
2012 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study.
|
21263130 |
2011 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies five new breast cancer susceptibility loci.
|
20453838 |
2010 |
|
Malignant neoplasm of breast
|
0.200 |
Biomarker
|
disease |
BEFREE |
These findings warrant studies of NHE1 as a potential target in breast cancer and demonstrate that in spite of their similar transport functions, NHE1 and NBCn1 serve different functions in MCF-7 cells.
|
20542029 |
2010 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Of the 9 polymorphisms investigated, 7 were associated with breast cancer for BRCA2 carriers (FGFR2, TOX3, MAP3K1, LSP1, 2q35, SLC4A7, 5p12, P = 7 × 10(-11) - 0.03), but only TOX3 and 2q35 were associated with the risk for BRCA1 carriers (P = 0.0049, 0.03, respectively).
|
21118973 |
2010 |
|
Malignant neoplasm of breast
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.
|
19330027 |
2009 |