All in all, it was proved in silico and supported with previously known clinical data that SLC4A7 and TMEM41B potentially have a significant and critical tumor suppressive role for PCa, and show this effect combinatorily working together.
Disruption of NBCn1 expression inhibited cell proliferation-evaluated by staining for the proliferative marker Ki67-particularly in central tumor areas with predicted increase in acid loading from glycolytic metabolism.
The Na<sup>+</sup>-HCO<sub>3</sub><sup>-</sup> cotransporter NBCn1 (SLC4A7) is up-regulated in breast cancer, important for tumor growth, and a single nucleotide polymorphism (SNP), rs4973768, in its 3' untranslated region (3'UTR) correlates with increased breast cancer risk.