Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Conclusion:</b> GDF15 might be a novel regulator of PD-L1 expression in GBMs; targeting GDF15/PD-L1 pathway might be a promising therapeutic approach for GBM patients.
|
31114328 |
2019 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Correction: Opposing Effects of PI3K/Akt and Smad-Dependent Signaling Pathways in NAG-1-Induced Glioblastoma Cell Apoptosis.
|
30281640 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, great progress has been made in understanding the influence of factors such as neurotensin, growth differentiation factor-15 (GDF-15), sphingosine-1-phosphate (S1P), and infection with cytomegalovirus (CMV) on the 'hallmarks of cancer' in glioblastoma multiforme.
|
29467963 |
2018 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of the GDF15 gene was investigated by qRT-PCR and overexpression was identified in both GBM cell lines.
|
29671197 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To elucidate the role of GDF-15 in glioblastoma in detail, we confirmed that glioma cells express GDF-15 mRNA and protein in vitro.
|
26741507 |
2016 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have previously found up-regulation of growth differentiation factor 15 (GDF15) in glioblastoma cells treated with the anticancer agent fenofibrate.
|
25645911 |
2015 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
NAG-1 expression is substantially increased during cancer development and progression especially in gastrointestinal, prostate, pancreatic, colorectal, breast, melanoma, and glioblastoma brain tumors.
|
23220538 |
2013 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that the proteasome inhibitors MG132 and bortezomib induced NAG-1 expression and secretion in glioblastoma cells.
|
23261467 |
2013 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The NAG-1 promoter was densely methylated in several glioblastoma cell lines as well as in primary oligodendroglioma tumor samples, which have low basal expression of NAG-1.
|
21437897 |
2012 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The high expression of GDF-15 in tumor tissue translates into elevated GDF-15 serum levels in glioblastoma patients compared with healthy controls.
|
20534737 |
2010 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome.
|
19521960 |
2009 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
In contrast to the documented proapoptotic and anti-tumorigenic activities of GDF-15 in several cancer cell lines, our data suggest that GDF-15 does not decrease proliferation of glioblastoma cell lines, while its effects on invasiveness are not consistent.
|
18550273 |
2008 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Oxygen deprivation, an important cellular stress, revealed MIC-1 as an anoxia responsive gene in glioblastoma cell lines.
|
12082608 |
2002 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Oxygen deprivation, an important cellular stress, revealed MIC-1 as an anoxia responsive gene in glioblastoma cell lines.
|
12082608 |
2002 |