TBPL1, TATA-box binding protein like 1, 9519

N. diseases: 198; N. variants: 1
Disease: Hyperalgesia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.030 Biomarker phenotype BEFREE Dysregulation of TRP channels is implicated in many pathologies, including cardiovascular diseases, muscular dystrophies and hyperalgesia. 28994450 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.030 Biomarker phenotype BEFREE Transient receptor potential ankyrin 1 (TRPA1), the most sensitive TRP channel to ROS, was shown to be responsible for urinary bladder abnormalities and hyperalgesia in an acute cystitis model. 29249972 2017
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.030 Biomarker phenotype BEFREE The prevention of this hyperalgesia by diclofenac (1-10μg), the inhibitors of COX-1 SC-560 (0.1-1μg) or COX-2 celecoxib (1-5μg), the TRPV1 antagonist capsazepine (0.03-0.3μg) or the TRPA1 antagonist HC030031 (10-50μg) demonstrates the involvement of prostaglandin synthesis and TRP sensitization in CCL5-evoked hyperalgesia. 28126501 2017