PTGES, prostaglandin E synthase, 9536

N. diseases: 150; N. variants: 2
Disease: Encephalomyelitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.030 Biomarker disease BEFREE Furthermore, mPGES-1 facilitated the autocrine function of VECs upon EP receptor induction and IL-1β production, modulating mPGES-1 induction in EAE. 30463256 2018
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.030 Biomarker disease BEFREE Therefore, mPGES-1 stimulates an intercellular interaction between CD4⁺ T cells by upregulating the autocrine function of IL-1β in activated CD4⁺ T cells, which release IL-17 to facilitate axonal and myelin damage in EAE mice. 29257087 2017
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.030 Biomarker disease BEFREE Thus, the mPGES-1-PGE(2)-EPs axis of the AA cascade may exacerbate EAE pathology. 19995978 2009