PTGES, prostaglandin E synthase, 9536

N. diseases: 150; N. variants: 2
Disease: Endometriosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.040 Biomarker disease BEFREE Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis. 31362919 2019
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.040 AlteredExpression disease BEFREE The expression levels of mPGES-1 mRNA in peritoneal endometriosis were higher than those in eutopic endometrium in the proliferative phase. 23252918 2013
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.040 Biomarker disease BEFREE By contrast, the cyclic stretch mimicking physiological peristalsis (3% elongation at 2 cycles/min) did not induce significant COX-2, mPGES-1 or PGE(2) production within 12 h. Both COX-2 and mPEGS-1 are PGE(2) synthases, and the aberrant COX-2 and PGE(2) production play important roles in the pathogenesis of endometriosis. 23239446 2012
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.040 Biomarker disease BEFREE Microsomal PGES immunoreactivity was observed in both epithelial cells and stromal or inflammatory cells of endometriosis. 17295901 2007
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.040 AlteredExpression disease LHGDN Microsomal PGES immunoreactivity was observed in both epithelial cells and stromal or inflammatory cells of endometriosis. 17295901 2007