PTGES, prostaglandin E synthase, 9536

N. diseases: 150; N. variants: 2
Disease: Colon Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.040 AlteredExpression disease BEFREE Thus, in addition to inhibitors of mPGES‑1 expression, EP4 antagonists and AKT/GSK-3β inhibitors may emerge as potential therapeutics to reduce CCR7 expression in colon cancer. 26352871 2015
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.040 Biomarker disease BEFREE This signaling provides a molecular explanation to PTGS2 and PTGES association and contribute to colon cancer advance, pointing out novel potential therapeutic targets in this oncological context. 26498686 2015
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.040 Biomarker disease BEFREE Genetic deletion of microsomal prostaglandin E synthase-1 (mPGES-1), the enzyme responsible for the second step of the PGE2 biosynthesis, has resulted in reduced tumor progression in mouse models of colon cancer. 26100239 2015
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.040 AlteredExpression disease BEFREE Changes in COX-2 and MGST1-L1 expression were not always coincident with a corresponding change in PGE(2) production by human colon carcinoma cells. 12818365 2003