|
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because hydroxychloroquine (HCQ) has been used frequently in the treatment of lupus, we sought to identify the effects of HCQ on CD154 and a possibly regulatory mechanism.
|
28793932 |
2017 |
|
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Association study of CD154 polymorphisms and serum CD154 level with systemic lupus erythematous in Chinese population.
|
28550400 |
2017 |
|
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
This activity was inhibited by anti-CD40L antibody, as well as anti-CD1d antibody, confirming a role for CD40L-CD40 and TCR-CD1d interactions in lupus iNKT-cell-mediated help.
|
25352488 |
2015 |
|
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Epigenetic deregulation of genes encoded on the X chromosome as reported for CD40L in lupus could explain the female predominance of autoimmune diseases.
|
24117612 |
2014 |
|
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, these findings provide some of the first evidence to support a possible mechanistic link to explain how the overexpression of IL-15 observed in lupus patients may be involved in the prolonged expression of CD154 that has also been observed on lupus CD4 T cells.
|
24500400 |
2014 |
|
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This suggests that demethylation of genes on the inactive X may predispose women to lupus, and this hypothesis is supported by a report that CD40LG, an immune gene encoded on the X chromosome, demethylates and is overexpressed in T cells from women but not men with lupus.
|
23434382 |
2013 |
|
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cell surface CD154 expression (pre- and postactivation) in peripheral blood CD4 T cells from 29 children with lupus and 29 controls matched for age, sex, and ethnicity was examined by flow cytometry.
|
20506525 |
2010 |
|
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that female lupus CD4+ T cells and demethylated CD4+ T cells express high level of CD40LG and overstimulate B cells to produce IgG.
|
19520616 |
2009 |
|
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Similar studies demonstrated that CD40LG demethylates in CD4(+) T cells from women with lupus, and that women but not men with lupus overexpress CD40LG on CD4(+) T cells, while both overexpress TNFSF7.
|
17947713 |
2007 |
|
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CD40L expression on activated lupus monocytes within anti-CD3-stimulated, mononuclear cell cultures was also enhanced compared to control-derived monocytes.
|
11987985 |
2002 |
|
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Lupus monocytes clearly overexpressed CD40L comparing to healthy and disease-control monocytes, and, similarly to lupus T cells, displayed a prominent resistance to CsA inhibitory effects.
|
12139375 |
2002 |
|
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lupus T cells cultured in medium containing 2-fluoroestradiol showed a significant (p = 0.04) increase in the amount of CD40L on the cell surface, but not in the number of positive cells, compared to the same T cells cultured without estradiol.
|
11764210 |
2001 |
|
Lupus Erythematosus, Discoid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recent data from SLE patients and murine lupus models have demonstrated prolonged expression of CD40L on lupus T cells and its capacity to mediate excessive B cell activation.
|
11604589 |
2001 |
|
Lupus Erythematosus, Discoid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black x New Zealand white mice. Response correlates with the absence of an anti-antibody response.
|
8816428 |
1996 |